Division of Hematopathology

The Division of Hematopathology, based at UPMC Presbyterian, has a broad and varied agenda achieving the classic academic triad of service, education and research. The Division staff includes nine faculty members with varied areas of expertise, three fellows and an administrative staff.

Faculty

Clinical Services

The Division serves as the Diagnostic Hematopathology resource for the UPMC-Health System as well as for others in our region and beyond. It is directly responsible for all the diagnostic hematopathology at Presbyterian and Shadyside Hospitals of UPMC, Childrens Hospital of Pittsburgh of UPMC, Magee Womens Hospital of UPMC, and the Hillman Cancer Center. In addition to a diagnostic lymph node/solid tissue and adult and pediatric bone morrow services, the Division provides the medical direction for a large Clinical Flow Cytometry Laboratory, a bone marrow laboratory and general hematology laboratories. The division has active Consultation Services, accepting both fresh specimens for full evaluation or for special studies as well as previously fixed specimens. We emphasize a multiparameter approach to hematopathology that incorporates morphology, flow cytometric and paraffin section immunophenotypic data, genotypic data from the Division of Molecular Oncology and classical and fluorescence in situ hybridization (FISH) cytogenetic data from the Pittsburgh Cytogenetics Laboratory. The Division is also participating in the development of array cytogenetic testing in the Department of Pathology.

Research Activities

The Division emphasizes several major areas of investigation. Current ongoing basic research focuses on identification of molecular mechanisms for the non-transcriptional inhibitory effects of estrogen on human osteoclastogenesis and on the role of erythropoietin receptor signaling in iron-deficiency anemia. A large area of ongoing investigations is the use of a multiparameter approach in the study principally of the non-Hodgkin lymphomas and related lymphoid proliferations as well as myeloid neoplasms. Specific areas of interest have included MALT lymphomas, other small B-cell lymphomas, aggressive B-cell lymphomas, cutaneous T-cell lymphomas and post-transplant lymphoproliferative disorders. Techniques range from standard morphology to complex genotypic studies including single nucleotide polymorphism (SNP) investigations. The role of flow cytometric studies in dealing with selected problems in diagnostic hematopathology such as myeloid neoplasms or the lymphoid microenvironment is another specific area of interest as is the evaluation of new instrumentation in diagnostic hematology. The Division also provides support for studies undertaken by our clinical colleagues.

Teaching

The Division is active in medical student education including a senior elective in hematopathology, providing longitudinal experiences for MD/PhD students and some graduate student education. The Division also has an ACGME accredited fellowship program (Hematopathology Fellowship) and a Special Institutional Education program (SIEP) for second year fellows and/or clinical instructors. Much of our educational efforts are spent on resident education and on training our hematopathology fellows. Rotations are also provided for clinical hematology/oncology fellows and other fellows in our department. More senior visitors a re also welcome. Divisional members are also involved in a variety of national/international teaching activities.

Training

The core hematopathology rotation of approximately 12 weeks offers the resident an introduction to the many facets of this complex field. The resident will begin to become familiar with the multiparameter approach to adult and pediatric diagnostic hematopathology (bone marrows and lymph nodes) as well as with techniques used in the hematology and the flow cytometry laboratories. Finally he/she will learn about major neoplastic and non-neoplastic disease entities that involve the hematopoietic and lymphoid cell lineages. If interested, more advanced rotations can be arranged in one or more areas within the division. It is recognized that the resident cannot fully achieve all of the objectives listed within a period of 12 weeks.

Core Curriculum

  • Lymph node pathology (~4 weeks)
  • Pediatric Hematopathology and Laboratory Hematology (~3 weeks)
  • Clinical hematology mini-rotation including performance of bone marrow aspirations and biopsies (with Hematology/BMT Division) (1/2 week)
  • Flow Cytometry mini-rotation (1/2 week)
  • Adult Bone Marrow pathology (~4 weeks)