Division of Hematopathology The Division of Hematopathology, based at UPMC-Presbyterian, has a broad and varied agenda achieving the classic academic triad of service, education and research. The Division staff includes seven faculty members with varied areas of expertise, two fellows and an administrative staff. Service: The Division serves as the Diagnostic Hematopathology resource for the UPMC-Health System and The Children's Hospital of Pittsburgh (CHP) as well as for others in our region and beyond. It is directly responsible for all the diagnostic hematopathology at UPMC-Presbyterian, UPMC-Shadyside and CHP. In addition to diagnostic lymph node/solid tissue and adult and pediatric bone marrow services, the Division supervises a large Flow Cytometry Laboratory, a bone marrow laboratory and the general hematology laboratories located at UPMC-Presbyterian, UPMC-Shadyside, Magee-Womens Hospital and Childrens Hospital of Pittsburgh. The division has active Consultation Services, accepting both fresh specimens for full evaluation or for special studies as well as previously fixed specimens. We emphasize a multiparameter approach to hematopathology that incorporates morphology, flow cytometric and paraffin section immunophenotypic data, genotypic data from the Division of Molecular Oncology and classical and fluorescence in situ hybridization (FISH) cytogenetic data from the Pittsburgh Cytogenetics Laboratory. Education: The Division is active in medical student education including a senior elective in hematopathology. Much of our educational efforts are spent on resident education and on training our hematopathology fellows. Electives are also provided for clinical hematology/oncology fellows and other fellows in our department. More senior visitors are also welcome. Divisional members are also involved in a variety of national/international teaching activities. Resident Rotation: The core hematopathology rotation of approximately 12 weeks offers the resident an introduction to the many facets of this complex field. The resident will begin to become familiar with the multiparameter approach to adult and pediatric diagnostic hematopathology (bone marrows and lymph nodes) as well as with techniques used in the general and special hematology and the flow cytometry laboratory. Finally he/she will learn about major neoplastic and non-neoplastic disease entities that involve the hematopoietic and lymphoid cell lineages. If interested, more advanced rotations can be arranged in one or more areas within the division. It is recognized that the resident cannot fully achieve all of the objectives listed within a period of 12 weeks. Core Resident Rotation Curriculum : Pediatric Hematopathology and General/Special Hematology Laboratory (~3 weeks) Clinical hematology mini-rotation including performance of bone marrow aspirations and biopsies (with Hematology/BMT Division) (1/2 week) Flow Cytometry mini-rotation (1/2 week) Adult Bone Marrow pathology (~4 weeks) Lymph node pathology (~4 weeks) Research: : The Division emphasizes several major areas of investigation. Current ongoing basic research focuses on the roles of cell signaling abnormalities in the development and progression of acute leukemia. A large area of ongoing investigations is the use of a multiparameter approach in the study principally of the non-Hodgkin lymphomas and related lymphoid proliferations. Specific areas of interest have included MALT lymphomas, other small B-cell lymphomas, aggressive B-cell lymphomas, cutaneous T-cell lymphomas and post-transplant lymphoproliferative disorders. Techniques range from standard morphology to complex genotypic studies including single nucleotide polymorphisms (SNP) investigations. The role of flow cytometric studies in dealing with selected problems in diagnostic hematopathology such as myeloid neoplasms or the lymphoid microenvironment is another specific area of interest as is the evaluation of new instrumentation in diagnostic hematology. The Division also provides support for studies undertaken by our clinical colleagues.