Molecular Diagnostics

The following is a list of all tests available from the Division of Molecular Diagnostics. Click on a test to see more information, including specimen types accepted, clinical significance, and type of analysis.

Section I: Microbiology, Virology, and Infectious Diseases

Core PCR Laboratory

The following tests are available from the Core PCR Laboratory:

* Lyme Disease
* Cytomegalovirus (CMV)
* Hepatitis C virus (HCV)
* Hepatitis B virus (HBV)
* Human T-cell lymphoma/leukemia virus-I (HTLV-I)
* Human T-cell lymphoma/leukemia virus-II (HTLV-II)
* Human immunodeficiency virus (HIV-I)
* Quantitative hepatitis C virus (HCV)
* Quantitative cytomegalovirus (CMV)
* Influenza virus
* Parainfluenza virus
* Adenoviruses (Types 2 + 5)
* HSV
* VZV
* HPV generic
* HPV 6,11,16,18,31,33
* Moraxella catarrhalis
* Streptococcus pneumonia
* Haemophilus influenza
* Bordetella pertussis
* Legionella spp.

For a list of tests in development within the Core PCR Laboratory, please click here.

Magee-Womens Hospital Molecular Diagnostics Laboratory

The following tests are available from the Magee-Womens Hospital Molecular Diagnostics Laboratory:

* Chlamydia
* Human parvovirus B19
* Candida albicans
* Candida glabrata
* Candida parapsilosis
* Candida tropicalis
* Group B streptococcus

For a list of tests in development within the Magee-Womens Hospital Molecular Diagnostics Laboratory, please click here.

Section II: Anatomic and Transplant Pathology

Molecular Tissue Typing Laboratory

The following tests are available from the Molecular Tissue Typing Laboratory:

* HLA typing DRB - low resolution
*HLA typing DRB - high resolution (subtyping)
* HLA typing DQB
*Bone marrow engraftment studies
* HLA DR typing (Rapid test)

For a list of tests in development within the Molecular Tissue Typing Laboratory, please click here.

In Situ Hybridization Laboratory

The following tests are available from the In Situ Hybridization Laboratory:

*HPV (Panel probe)
* HPV 6 and 11 subtype probe
*HPV 16 and 18 subtype probe
*HPV 31, 32, and 33 subtype probe
*Adenovirus probe
* CMV probe
* EBV probe
* HSV probe
*mRNA/Kappa chain restrictions
*mRNA/Lambda chain restrictions
* Y chromosome specific probe

Section III: Molecular Oncology

Molecular Oncology Laboratory

The following tests are available from the Molecular Oncology Laboratory:

*Immunoglobin heavy chain gene rearrangement
*Immunoglobin kappa light chain gene rearrangement
*Immunoglobin lambda light chain gene rearrangement
*T-cell receptor beta-chain gene rearrangement
* bcl-2 gene rearrangement
*c-myc gene rearrangement
* neu gene rearrangement
*c-myc gene amplification
* int-2 gene amplification
* N-myc gene amplification
* EGFR gane amplification
* t(9;22), bcr-abl translocation
*t(9;22), bcr-abl (ALL variant) translocation
* t(15;17), pml-rar translocation
* t(1;19), pbxl-E2A translocation
* Epstein-Barr virus terminal repeat DNA analysis
* rar-alpha gene rearrangement
* mll-1 gene rearrangement

For a list of tests in development within the Molecular Oncology Laboratory, please click here.

Section IV: Molecular Genetics

PGI/CLSI Federated Diagnostic Molecular Genetics Laboratory

The following tests are available from the PGI/CLSI Federated Diagnostic Molecular Genetics Laboratory:

*Cystic fibrosis
*Gaucher disease
*Medium chain acyl dehydrogenase deficiency
* Quantitative X-inactivation
* Myotonic dystrophy
*Sodium channelopathies
*Chloride channelopathies
*Duchenne/Becker muscular dystrophy

For a list of tests in development within the PGI/CLSI Federated Diagnostic Molecular Genetics Laboratory, please click here .

* The University of Pittsburgh Medical Center is a participant in the Reference Laboratory Alliance (RLA), a wholly owned subsidiary of the Institute for Transfusion Medicine that offers laboratory and related services formerly provided by Central Blood Bank, and administers and markets services provided by major reference laboratories, including the UPMC, Magee-Womens Hospital, Children's Hospital of Pittsburgh, Allegheny General Hospital, and other laboratories supervised by the Pathology Education and Research Foundation.