Hematopathology Center of Excellence


CD123 immunohistochemical stain, Castleman Disease

Mission Statement

The Division of Hematopathology, based at UPMC Presbyterian, has a broad and varied agenda achieving the classic academic triad of service, education and research. The Division staff includes nine faculty members with varied areas of expertise, three fellows, and an administrative staff.


The Division based at UPMC-Presbyterian and the Clinical Laboratory Building serves as the Diagnostic Hematopathology resource for the UPMC Health System, as well as for others in our region and beyond. It is directly responsible for all the diagnostic hematopathology at UPMC Presbyterian, UPMC Shadyside, The Hillman Cancer Center, and The Childrens Hospital of Pittsburgh. In addition to diagnostic lymph node/solid tissue and adult and pediatric bone marrow services, the Division supervises a large Flow Cytometry Laboratory, the general hematology laboratories that serve UPMC Presbyterian, UPMC Shadyside, and Magee-Womens Hospital. The division has active Consultation Services, accepting both fresh specimens for full evaluation or for special studies as well as previously fixed specimens. We emphasize a multiparameter approach to hematopathology that incorporates morphology, flow cytometric and paraffin section immunophenotypic data, genotypic data from the Division of Molecular Oncology and classical and molecular cytogenetic data from the Pittsburgh Cytogenetics Laboratory.


The Division is active in medical student education including a senior elective in hematopathology, providing longitudinal experiences for MD/PhD students and some graduate student education. The Division also has an ACGME accredited fellowship program (Hematopathology Fellowship) and a Special Institutional Education program (SIEP) for second year fellows and/or clinical instructors. Much of our educational efforts are spent on resident education and on training our hematopathology fellows. Rotations are also provided for clinical hematology/oncology fellows and other fellows in our department. Divisional members are also involved in a variety of national/international teaching activities.


The Division emphasizes several major areas of investigation. Current ongoing basic research focuses on the role of erythropoietin receptor signaling in iron-deficiancy anemia. A large area of ongoing investigation is the use of a multiparameter approach in the study principally of the non-Hodgkin lymphomas and related lymphoid proliferations as well as myeloid neoplasms. Specific areas of interest have included small B-cell lymphomas, aggressive B-cell lymphomas, T-cell lymphomas and post-transplant lymphoproliferative disorders. Techniques range from standard morphology to compleg genotypic studies. The role of flow cytometric studies in dealing with selected problems in diagnostic hematopathology such as myeloid neoplasms or the lymphoid microenvironment is another specific area of interest as is the evaluation of new instrumentation in diagnostic hematology. The Division also provides support for studies undertaken by our clinical colleagues.