Hematopathology Faculty Steven H. Swerdlow, MD Lydia Contis, MD Fiona Craig, MD Miroslav Djokic, MD Sandra Kaplan, MD Sara Monaghan, MD Sonam Prakash, MD Lisa Robinson, MD Mission Statement The Division of Hematopathology, based at UPMC-Presbyterian, has a broad and varied agenda achieving the classic academic triad of service, education and research. The Division staff includes six faculty members with varied areas of expertise, two fellows and an administrative staff. Service: The Division serves as the Diagnostic Hematopathology resource for the UPMC-Health System and The Children's Hospital of Pittsburgh (CHP) as well as for others in our region and beyond. It is directly responsible for all the diagnostic hematopathology at UPMC-Presbyterian, UPMC-Shadyside and CHP. In addition to diagnostic lymph node/solid tissue and adult and pediatric bone marrow services, the Division supervises a large Flow Cytometry Laboratory, a special hematology laboratory and the general hematology laboratories located at UPMC-Presbyterian and UPMC-Shadyside. The division has active Consultation Services, accepting both fresh specimens for full evaluation or for special studies as well as previously fixed specimens. We emphasize a multiparameter approach to hematopathology that incorporates morphology, flow cytometric and paraffin section immunophenotypic data, genotypic data from the Division of Molecular Oncology and conventional and other cytogenetic data from the Pittsburgh Cytogenetics Laboratory. Education: The Division is active in medical student education including a senior elective in hematopathology. Much of our educational efforts are spent on resident education and on training our hematopathology fellows. Electives are also provided for clinical hematology/oncology fellows and other fellows in our department. More senior visitors are also welcome. Divisional members are also involved in a variety of national/international teaching activities. Research: The Division emphasizes several major areas of investigation. Current ongoing basic research focuses on the roles of cell signaling abnormalities in the development and progression of acute leukemia. A large area of ongoing investigations is the use of a multiparameter approach in the study principally of the non-Hodgkin lymphomas and related lymphoid proliferations. Specific areas of interest have included MALT lymphomas (especially of the salivary gland), other extranodal B-cell lymphomas, diffuse large B-cell lymphomas and post-transplant lymphoproliferative disorders. Techniques range from standard morphology to complex genotypic studies. The role of flow cytometric studies in dealing with selected problems in diagnostic hematopathology is another specific area of interest as in the evaluation of new instrumentation in diagnostic hematology. Cutaneous lymphoid infiltrates are also being studied. The Division also provides support for studies undertaken by our clinical colleagues.