DEPARTMENT OF PATHOLOGY DIVISIONS Anatomic Pathology Anatomic Pathology services at the University of Pittsburgh are based on a diagnostic Centers of Excellence model and encompass surgical pathology, cytopathology, transplantation pathology and autopsy pathology. All pathology material (90,000 surgicals, 140,000 cytologies) received from our four major teaching hospitals (Presbyterian University Hospital, Shadyside University Hospital, Magee Women's Hospital, and Children's Hospital of Pittsburgh) is triaged to specialty benches organized by organ system. Material on these subspecialty benches is signed out by diagnostic pathologists who have particular subspecialty interest and training in that organ system, which provides patients with the best care and physicians with ideal collaborative relationships for bench-to-bedside investigation. Resident and fellow training is fundamental to the Centers of Excellence model. Each subspecialty area has well defined goals and teaching styles, each providing housestaff officers with comprehensive teaching sets, reference lists, weekly goals and research endeavors. Specialty fellows on each bench help provide continuity of clinical care and teaching to all housestaff officers rotating between benches, and assist in preparation of organ specific clinicopathologic conferences. The clinical practice of Anatomic Pathology at the University of Pittsburgh is supported by several core laboratories based at Presbyterian Hospital, including the Molecular Anatomic Pathology (MAP) core facility, the fluorescence in situ hybridization/array comparative genomic hybridization core facility and the immunohistochemistry core facility. These core facilities also provide research opportunities for pathology faculty and pathologists-in-training. Centers of Excellence (COE) in Anatomic Pathology at the University of Pittsburgh Autopsy COE Bone and Soft Tissue Pathology COE Cytopathology COE Dermatopathology COE Gastrointestinal Pathology COE Genitourinary PathologyCOE Breast and Gynecologic Pathology COE Head and Neck (ENT) Pathology COE Hematopathology COE Medical Renal Pathology COE Neuropathology COE Thoracic COE Transplantation and Hepatic Pathology COE Anatomic Pathology Fellowships Core Laboratories within the Division of Anatomic Pathology Molecular Anatomic Pathology Lab: The MAP lab provides patients, clinicians, and national investigators with unique molecular testing of formalin fixed paraffin embedded tissue that is helpful in the diagnosis and prognostication of inflammatory and neoplastic disease. Using loss of heterozygosity analysis, methylation studies, DNA sequencing, and microsatellite instability testing, among others, material received in the surgical pathology laboratory is assessed for unique genomic abnormalities. In addition, this testing can be utilized for research projects by faculty and housestaff officers alike. FISH/CGH Lab: The fluorescence in situ hybridization/array comparative genomic hybridization laboratory allows us to study solid tumors and transplant cases utilizing in situ hybridization assays and a commercial Abbott/Vysis CGH chip. This would include analyses for microchimerism, translocations, and gene amplifications that are essential to the practice of surgical pathology in the 21st century. Immuno Lab: The two molecular laboratories supplement an enormous clinical and research immunohistochemistry laboratory, which provides a comprehensive and extensive array of antibodies for immunohistochemical analysis of various cellular glycoproteins. Autopsy: The Autopsy Service based at Presbyterian handles all autopsies for UPMC Presbyterian and Shadyside as well as the hospitals that comprise our community division. Approximately 300 autopsies are done per year and these autopsies are managed by a devoted group of autopsy pathologists lead by Lawrence Nichols, MD. Anatomic Pathology Consultation Services Center for Pathology Informatics Pathology at the Veterans Affairs Pittsburgh Healthcare System