Stephen F. Badylak, Professor
Department of Surgery
Deputy Director, The McGowan Institute for Regenerative Medicine
DVM, Purdue University, 1976
PhD, Purdue University, 1981
MD, Indiana University Medical School, 1985
Email: badylaks@upmc.edu
Research Interest:
Dr. Stephen Badylak is a Professor in the Department of Surgery and deputy director of the McGowan Institute for Regenerative Medicine at the University of Pittsburgh. Dr. Badylak holds over 40 US patents and 200 patents worldwide and has authored more than 190 scientific publications and 12 book chapters. He has served as the Chair of the Purdue University Tissue Engineering Advisory Board and as chair of several Study Sections for the National Institutes of Health (NIH), including the Bioengineering, Technology, and Surgical Sciences Study Section. Dr. Badylak has either chaired or been a member of the Scientific Advisory Board to several major medical device companies.
Dr. Badylak is a Fellow of the American Institute for Medical and Biological Engineering. He is a charter member and president-elect of the Tissue Engineering Regenerative Medicine International Society (TERMIS). Dr. Badylak is a member of the Society for Biomaterials and the International Society for Applied Cardiovascular Biology (ISACB).
Dr. Badylak is the Associate Editor for Tissue Engineering for the journal Cells, Tissues, Organs. For his contributions to the fields of Regenerative Medicine and Biomaterials, he has been the recipient of awards such as the Sigma Xi Scientific Society 2002 Research Award, the Clemson Award - (Society for Biomaterials) in 2005, Pittsburgh Business Times Hero in Healthcare finalist - 2005, the Carnegie Science Center Award for Excellence - in 2005 and 2008, and the Chancellor's Distinguished Research Award in 2008.
Dr. Badylak's laboratory is a highly interdisciplinary environment. The major focus of the laboratory is the development of regenerative medicine strategies for tissue and organ replacement. The use of mammalian extracellular matrix (ECM) or its derivatives as an inductive template for constructive remodeling of tissue is a common theme of most research activities. The goal of all projects is clinical translation and improved patient care.
Most projects involve the combined efforts of life scientists, biomedical engineers, physicians, veterinarians, and a strong technical support staff. Major Research Interests include: Cell-matrix interactions and cell signaling, Biomaterials and Biomaterial/Tissue interactions, Biomedical Engineering as it Relates to Device Development and Biomaterials, and Developmental Biology and its role in Regenerative Medicine.
Active Research Projects include: Mechanisms of matrix scaffold remodeling in esophageal, tracheal, cardiovascular, lower urinary tract and musculotendinous tissue reconstruction, Immune response of mammals to xenogeneic scaffolds, Autologous stem cell recruitment in vivo during tissue reconstruction, Degradation of ECM scaffolds and bioactive degradation products, Mechanobiology and its relationship to tissue reconstruction, and Development of bioscaffolds for liver regeneration.
The Badylak laboratory thrives upon the collaborative efforts of its personnel. Currently there are five staff scientists (including cell biologists, engineers, immunologists, and molecular biologists), seven doctoral students, three post doctoral fellows, four technicians, two administrative assistants, one MD-PhD student, and approximately six undergraduate students. There are typically two or three visiting scientists in the laboratory and two or three clinical-surgeons involved in every active project.
For details of current projects, and members of the Center for Preclinical Studies, please visit: http://www.mirm.pitt.edu/badylak/
Recent Publication
Marra, K.G.; DeFail, A.J.; Clavijo-Alvarez, J.A.; Badylak, S.F.; Taieb, A.; Schipper, B.; Bennett, J.; Rubin, J.P. FGF-2 Enhances Vascularization for Adipose Tissue Engineering. Plastic Recon. Surg 2008 Apr; 121(4):1153-64.
Gilbert, T.W., Nieponice, A., Spievack, A., Holcomb, J., Gilbert, S., Badylak, S.F. Repair of the Thoracic Wall with an Extracellular Matrix Scaffold in a Canine Model. J. Surg Res. 2008. June 1;147(1):61-7.
Freytes, D.O., Martin, J., Velankar, S.S., Lee, A.S., Badylak, S.F. Preparation and Rheological Characterization of a Gel Form of the Porcine Urinary Bladder Matrix. Biomaterials, 2008 29:1630-1637.
Gilbert, T. W., Badylak, S. F., Gusenhoff, J., Beckman, E. J., Clower, D.M., Daly, P., Rubin, J. P. Lysine-Derived Urethane Surgical Adhesive Prevents Seroma Formation in a Canine Abdominoplasty Model. Plastic and Reconstructive Surgery 2008 Jul;122(1):95-102.
Gilbert, T. W., Freund, J. M., Badylak, S. F. Quantification of DNA in Biologic Scaffold Materials. J. Surg Res. 2008 May
Badylak, S.F. and Gilbert, T.W. Immune Response to Biologic Scaffold Materials. Seminars in Immunology, 2008 20:109-116.
Badylak, S. F., Valentin, J., Ravindra, A., McCabe, G., Stewart-Akers, A. Macrophage Phenotype as a Determinant of Biologic Scaffold Remodeling. Tissue Engineering (in press).
Reing, J.E., Zhang, L., Myers-Irvin, J., Cordero, K.E., Freytes, D.O., Heber-Katz, E., Bedelbaeva, K., McIntosh, D., Abiche, D., Braunhut, S.J., Badylak, S.F. Degradation Products of Extracellular Matrix Affect Cell Migration and Proliferation. Tissue Engineering. (in press)
Brennan, E.P., Tang, X-H., Stewart-Akers, A.M., Gudas, L.J., Badylak, S.F. Chemoattractant activity of degradation products of fetal and adult skin extracellular matrix for keratinocyte progenitor cells. Journal of Tissue Engineering and Regenerative Medicine. (in press).
Gilbert, T.W., Gilbert, S., Madden, M., Reynolds, S.D., Badylak, S.F. Morphologic Assessment of Extracellular Matrix Scaffolds for Patch Tracheoplasty in a Canine Model. Annals of Thoracic Surgery. 2008 Sept 86(3):967-974.
Nieponice, A., McGrath, K., Qureshi, I., Beckman, E.J., Luketich, J.D., Gilbert, T.W., Badylak, S.F. An Extracellular Matrix Scaffold for Esophageal Stricture Prevention After Circumferential Endoscopic Mucosal Resection. Gastrointestinal Endoscopy. (in press)
Valentin, Jolene E., Freytes, Donald O., Grasman, Jonathan M., Pesyna, Colin, Freund, John, Gilbert, Thomas W., Badylak, Stephen F. Oxygen Diffusivity of Biologic and Synthetic Scaffold Materials for Tissue Engineering. Journal of Biomedical Materials Research: Part A. (in press)
Beattie, Allison J., Gilbert, Thomas W., Guyot, Juan Pablo, Yates, Adolph J., Badylak, Stephen F. Chemoattraction of Progenitor Cells by Remodeling Extracellular Matrix Scaffolds. Tissue Engineering: Part A. 2008. October
Crisan, Mihaela, Yap, Solomon, Casteilla, Louis, Chen, Chien-Wen, Corselli, Mirko, Park, Tea Soon, Sun, Bin, Zheng, Bo, Zhang, Li, Norotte, Cyrille, Teng, Pang-Ning, Traas, Jeremy, Schugar, Rebecca, Deasy, Bridget M., Andriolo, Gabriella, Badylak, Stephen F., Bhring, Hans- Jörg, Lazzari, Lorenza, Giacobino, Jean-Paul, Huard, Johnny, Péault, Bruno. A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs. Cell Stem Cell. 2008 Sept 3(1-13).
Ota, T., Gilbert, T.W., Schwartzman, D., McTiernan, C.F., Kitajima, T., Ito, Y., Sawa, Y., Badylak, Stephen F., Zenati, M.A. A Fusion Protein of Hepatocyte Growth Factor Enhances Reconstruction of Myocardium in a Cardiac Patch Derived from Porcine Urinary Bladder Matrix. J Thorac Cardiovasc Surg. (In Press)
Gilbert, Thomas W., Wognum, Silvia, Joyce, Erinn M., Freytes, D.O., Sacks, Michael S., Badylak, Stephen F. Collagen Fiber Architecture and Biaxial Mechanical Behavior of Porcine Urinary Bladder Derived Extracellular Matrix. Biomaterials. (in press)
Badylak, Stephen F., Freytes, D.O., Gilbert, Thomas W. Extracellular Matrix as a Biologic Scaffold Material: Structure vs. Function. Acta Biomaterialia. (in press).
Valentin, Jolene E., Stewart-Akins, A., Gilbert, Thomas W., Badylak, Stephen F. Macrophage Participation in the Degradation and Remodeling of ECM Scaffolds. Tissue Engineering. (in press)
