Yoram Vodovotz, Associate Professor
Ph.D., Cornell University Graduate School of Medical Sciences, 1993
Associate Professor of Surgery
W1542 Biomedical Sciences Tower
200 Lothrop St.
Pittsburgh, PA 15213
Phone: (412) 647-5609
Email: vodovotzy@upmc.edu; or vodovotz@pitt.edu
My research interests include the biology of shock states (e.g. septic and hemorrhagic shock) and the role various inflammatory mediators in shock. I am also interested in the cross-regulation of the inducible nitric oxide synthase (iNOS) and the cytokine transforming growth factor-beta-1 (TGF-beta-1) in various disease states, including malaria infection, cancer, sepsis, and neurodegenerative diseases. A recent and very exciting area of interest revolves around the mathematical modeling of various biological interactions. As the Director of the Center for Inflammation and Regenerative Modeling (CIRM; www.mirm.pitt.edu/cirm) at the McGowan Institute for Regenerative Medicine, I have been involved in the mathematical modeling of shock states (e.g. septic or hemorrhagic shock), including cellular and physiological elements, as part of a large, interdisciplinary collaborative team.
Recent Publication
Luckhart, S.; Crampton, A. L.; Zamora, R.; Lieber, M. J.; Dos Santos, P. C.; Peterson, T. M. L.; Emmith, N.; Lim, J.; Wink, D. A.; Vodovotz, Y. Mammalian transforming growth factor-b1 activated after ingestion by Anopheles stephensi modulates mosquito immunity. Infect.Immun. 2003. 71:3000-3009.
Clermont, G.; Bartels, J.; Kumar, R.; Constantine, G.; Vodovotz, Y.; Chow, C. In silico design of clinical trials: a method coming of age. Crit Care Med. 2004. 32:2061-2070.
Chow, C. C.; Clermont, G.; Kumar, R.; Lagoa, C.; Tawadrous, Z.; Gallo, D.; Betten, B.; Bartels, J.; Constantine, G.; Fink, M. P.; Billiar, T. R.; Vodovotz, Y. The acute inflammatory response in diverse shock states. Shock 2005. 24:74-84.
Prince, J.M.; Levy,R.M.; Bartels, J.; Baratt, A.; Kane, J.M. III; Lagoa, C.; Rubin, J.; Day, J.; Wei, J.; Fink, M.P.; Goyert, S.; Clermont, G.; Billiar, T.R.; Vodovotz, Y. In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice. Mol. Med., 2006. 12:88-96.
Lagoa, C.E.; Bartels, J.; Baratt, A.; Tseng, G.; Clermont, G.; Fink, M.P.; Billiar, T.R.; Vodovotz, Y. The role of initial trauma in the host¡¯s response to injury and hemorrhage: Insights from a comparison of mathematical simulations and hepatic transcriptomic analysis. Shock, 2006. 26:592-600.
Kumar, R.; Chow, C.C.; Bartels, J.; Clermont, G.; Vodovotz, Y. A mathematical simulation of the inflammatory response to anthrax infection. Shock. 2007. (In Press).
