Yoram Vodovotz, Professor
Ph.D., Cornell University Graduate School of Medical Sciences, 1993
Director, Center for Inflammation and Regenerative Modeling
Professor of Surgery, Immunology, Clinical and Translational Science, and Communication Science and Disorders
Visiting Professor of Computational Biology
University of Pittsburgh
W944 Biomedical Sciences Tower
200 Lothrop St.
Pittsburgh, PA 15213
Phone: (412) 647-5609
Email: vodovotzy@upmc.edu; or vodovotz@pitt.edu
My research interests include the biology of shock states (e.g. septic and hemorrhagic shock) and the role various inflammatory mediators in shock. I am also interested in the cross-regulation of the inducible nitric oxide synthase (iNOS) and the cytokine transforming growth factor-beta-1 (TGF-beta-1) in various disease states, including malaria infection, cancer, sepsis, and neurodegenerative diseases. A recent and very exciting area of interest revolves around the mathematical modeling of various biological interactions. As the Director of the Center for Inflammation and Regenerative Modeling (CIRM; www.mirm.pitt.edu/cirm) at the McGowan Institute for Regenerative Medicine, I have been involved in the mathematical modeling of shock states (e.g. septic or hemorrhagic shock), including cellular and physiological elements, as part of a large, interdisciplinary collaborative team.
Recent Publication
Kumar, R.; Clermont, G.; Vodovotz, Y.; Chow, C. C. The dynamics of acute inflammation. J.Theoretical Biol. 2004. 230:145-155.
Chow, C. C.; Clermont, G.; Kumar, R.; Lagoa, C.; Tawadrous, Z.; Gallo, D.; Betten, B.; Bartels, J.; Constantine, G.; Fink, M. P.; Billiar, T. R.; Vodovotz, Y. The acute inflammatory response in diverse shock states. Shock 2005. 24:74-84.
Prince, J.M.; Levy,R.M.; Bartels, J.; Baratt, A.; Kane, J.M. III; Lagoa, C.; Rubin, J.; Day, J.; Wei, J.; Fink, M.P.; Goyert, S.; Clermont, G.; Billiar, T.R.; Vodovotz, Y. In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice. Mol. Med., 2006. 12:88-96.
Lagoa, C.E.; Bartels, J.; Baratt, A.; Tseng, G.; Clermont, G.; Fink, M.P.; Billiar, T.R.; Vodovotz, Y. The role of initial trauma in the host's response to injury and hemorrhage: Insights from a comparison of mathematical simulations and hepatic transcriptomic analysis. Shock, 2006. 26:592-600.
Vodovotz, Y. Deciphering the complexity of acute inflammation using mathematical models. Immunologic Res. 2006. 36:237-246.
Mi, Q.; Rivière, B.; Clermont, G.; Steed, D.L. ; Vodovotz, Y. Agent-based model of inflammation and wound healing: insights into diabetic foot ulcer pathology and the role of transforming growth factor-b1. Wound Repair Reg. 2007. 15:671-682.
Kumar, R.; Chow, C.C.; Bartels, J.; Clermont, G.; Vodovotz, Y. A mathematical simulation of the inflammatory response to anthrax infection. Shock. 2008. 29:104-111
Li, N.Y.K.; Verdolini, K.; Clermont, G.; Mi, Q.; Hebda, P.A.; Vodovotz, Y. A patient-specific in silico model of inflammation and healing tested in acute vocal fold injury. PLoS ONE. 2008. 3:e2789.
Vodovotz, Y., Csete, M.; Bartels, J.; Chang, S.; An, G. Translational systems biology of inflammation. PLoS Comput. Biol. 2008. 4:1-6.
Drexler, A.L.; Vodovotz, Y.; Luckhart, S. Plasmodium development in the mosquito: biology bottlenecks and opportunities for mathematical modeling. Trends Parasitol. 2008. 24:333-336.
Rivière, B.; Epshteyn, Y.; Swigon, D.; Vodovotz, Y. A simple mathematical model of signaling resulting from the binding of lipopolysaccharide with Toll-like receptor 4 demonstrates inherent preconditioning behavior. Math. Biosci. 2009. 217:19-26.
Torres, A.; Bentley, T.; Bartels, J.; Namas, R.; Zamora, R.; Puyana, J.C.; Vodovotz, Y. Mathematical modeling of post-hemorrhage inflammation in mice: Studies using a novel, computer-controlled, closed-loop hemorrhage apparatus. Shock. 2009. 32:172-178.
Wognum, S.; Lagoa, C.; Nagatomi, J.; Sacks, M.S.; Vodovotz, Y. An exploratory temporal analysis of the rat bladder wall transcriptome after spinal cord injury: Insights on remodeling, inflammation and infection using pathways analysis. PLoS ONE. 2009. 4:e582.
Vodovotz, Y. Translational systems biology of inflammation and healing. Wound Repair Regen. 2010. 18:3-7.
Brown, B.; Price, I.; Toapanta, F.R.; DeAlmeida, D.R.; Wiley, C.A.; Ross, T.M.; Oury, T.D.; Vodovotz, Y. An Agent-based model of inflammation and fibrosis following particulate exposure in the lung. Math. Biosci. 2011. 231:186-196.
Mi, Q.; Constantine, G.; Ziraldo, C.; Solovyev, A.; Torres, A.; Namas, R.; Bentley, T.; Billiar, T.R.; Zamora, R.; Puyana, J.C.; Vodovotz, Y. A dynamic view of trauma/hemorrhage-induced inflammation in mice: Principal drivers and networks. PLoS ONE. 2011.6:19424.
