Pathology Graduate Training Program
Cellular and Molecular Pathology (CMP) -
Current Graduate Students

Name:Nisha Sambamurthy
Email: nis21pitt@gmail.com
Lab Phone: 412-624-4325
Mentor Name: Dr. Steven D. Shapiro

Undergraduate Education:
Undergraduate Degree: B.Tech Biotechnology
Undergraduate Institution: Anna University

Research Project Information

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of mortality in the developed world. Mainly caused by exposure to cigarette smoke, this disease leads to permanent and irreversible damage to the airways and the lung parenchyma. My research focuses on understanding the role for the receptor of advanced glycation end products (RAGE) in the pathogenic progression of this disease using a model model of COPD. I am additionally, interested in endogenous cellular players that could be involved in repair under conditions of cigarette smoke induced injury. One such cell type, characterized to be present in the broncho-alveolar duct junction, is the broncho-alveolar stem cell (BASC). We have developed a transgenic mouse model at the lab to lineage trace these cells and track their movement into the alveolar compartment post-injury. We hope to utilize this mouse model to investigate the contribution of the BASCs to alveolar repair post-injury.

Publications / Achievements

Publications

In Preparation.

Abstracts:

Sambamurthy N et al. Receptor for advanced glycation end products- a mediator of cigarette smoke induced Emphysema in a mouse model for COPD American Thoracic Society International conference, 2013

Sambamurthy N et al. Reparative role of Matrix metalloproteinase 9 (MMP-9) in models of COPD, American Thoracic Society International conference, 2010