Pathology Graduate Training Program
Cellular and Molecular Pathology (CMP) -
Alumni

Name: Judson Englert
Email: englert.judson@medstudent.pitt.edu
Lab Phone: 412-624-8888
Mentor Name: Tim Oury, MD, PhD

Undergraduate Education:
University of North Carolina at Chapel Hill
B.S. Chemistry with Highest Honors - May 2005

Research Project Information:

A role for the Receptor for Advanced Glycation End-Products (RAGE) in Idiopathic Pulmonary Fibrosis

Publications:

Kliment CR, Englert JM, Gochuico BR, Yu G, Kaminski N, Rosas I, Oury TD: Oxidative stress alters syndecan-1 distribution in lungs with pulmonary fibrosis, J Biol Chem 2009, 284:3537-3545

Englert JM, Hanford LE, Kaminski N, Tobolewski JM, Tan RJ, Fattman CL, Ramsgaard L, Richards TJ, Loutaev I, Nawroth PP, Kasper M, Bierhaus A, Oury TD: A role for the receptor for advanced glycation end products in idiopathic pulmonary fibrosis, Am J Pathol 2008, 172: 583-591.

Englert JM, Ramsgaard L, Valnickova Z, Enghild JJ, Oury TD: Large scale isolation and purification of soluble RAGE from lung tissue, Protein Expr Purif 2008, 61: 99-101.

Abstracts:

Englert, JM; Sparvero LJ; Amoscato, AA; Lotze, MT; Oury, TD. RAGE and the Lung ECM: A novel protective function. American Thoracic Society International Conference, San Diego, CA, USA, May 2009. (Abstract poster)

Englert, JM; Kaminski, N; Bierhaus, A; Oury, TD. Advanced Glycation End-Products Increase Diabetics' Suceptibility to Pulmonary Fibrosis. 15th International Colloquium on Lung Airway Fibrosis, Sunset Beach, NC, USA, September 2008.

Englert, JM; Sparvero, LJ; Amoscato, AA; Lotze, MJ; Oury, TD. RAGE and the Extra-cellular Matrix: A novel protective function. Damage Associated Molecular Pattern Molecules (DAMPs) and Alarmins Symposium, Pittsburgh, PA, USA, August 2008.

Englert, JM; Kaminski, N; Bierhaus, A; Oury, TD. Advanced Glycation End-Products Increase Diabetics' Suceptibility to Pulmonary Fibrosis. American Thoracic Society International Conference, Toronto, ON, Canada, May 2008.

Englert, JM; Tobolewski, J; Hanford, LE; Oury, TD. Advanced Glycation End-Products Competitively Inhibit the Binding of Extracellular Matrix Proteins by RAGE in the Lung. Annual MD/PhD Research Symposium, University of Pittsburgh, August 2006.

Englert, JM; Hanford, LE; Oury, TD. The Role of the RAGE Signaling Pathway in Disease Pathogenesis. Annual MD/PhD Research Symposium, University of Pittsburgh, August 2005.

Englert, JM; Moen, J; Wolberg, AS. The Role of Fibrinopeptide Release on Fibrin Clot Structure. XVIIIth Annual International Fibrinogen Workshop, Chapel Hill, NC, July 2004.

Laura Gray, Brittany Larson, Judson M. Englert, Robert A. Campbell, Mirella Ezban, Alisa S. Wolberg. 2008. Recombinant Factor VIIa Analog (V158D/E296V/M298Q-FVIIa, NN1731) Enhances Fibrin Formation, Structure and Stability in Hemophilic Plasma. 4th Symposium on Hemostasis with Special Focus on Factor VIIa & Tissue Factor - Understanding the Molecular Mechanism, Chapel Hill, NC

Laura Gray, Brittany Larson, Judson M. Englert, Robert A. Campbell, Mirella Ezban, Alisa S. Wolberg. 2008. Recombinant Factor VIIa Analog (V158D/E296V/M298Q-FVIIa, NN1731) Enhances Fibrin Formation, Structure and Stability in Hemophilic Plasma. Ninth Workshop on Novel Technologies and Gene Transfer for Hemophilia, Philadelphia, PA

Presentations:

Englert, JM. Understanding the paradox: The function of RAGE in models of pulmonary fibrosis. Department of Pathology 2009 Annual Retreat. University of Pittsburgh Medical Center. May 29, 2009.

Englert, JM. A tale of two models: RAGE in IPF. Pulmonary Medicine Conference. University of Pittsburgh Medical Center. February 27, 2009

Englert JM. A Role for RAGE in IPF. Pulmonary Medicine Weekly Conference. University of Nebraska Medical Center. January 3, 2008.

Englert JM; Wolberg AS. Role of Fibrinopeptide Release in Determining Fibrin Clot Structure during in situ Thrombin Generation. Annual Celebration of Undergraduate Research, University of North Carolina, April 2005.

Englert JM; Shultz, L. Pharmaceutical Evaluation of a Novel Antibiotic Compound. Pharmaceutical Research and Development Departmental Meeting, Merck Pharmaceuticals, August 2004.

Grant Support:

Ruth L. Kirschstein NRSA Fellowship
Title:    "A Role for Advanced Glycation End-Products in Diabetic Lung Injury"
Source/Project # or type (P.I.):    NIH / 1F30 ES016973-01 (Englert)
Project Period:    07/15/2008-07/14/2013
Costs (Direct/Indirect)    $ 40,788 - 45,972 / $0

Awards/Honors:

  • MSTP Grant Recipient (Institutional, T32) - National Institutes of Health- Sept. 2005-Sept. 2006
  • Student Commencement Speaker - UNC Department of Chemistry - May 2005
  • Merck Index Award for Outstanding Academic Performance - UNC Department of Chemistry - May 2005
  • B.S. Chemistry with Highest Honors - UNC-CH - May 2005
  • Phi Beta Kappa Honor Society - April 2004
  • Dean's List 6 of 7 eligible semesters, UNC-CH
  • University of North Carolina at Chapel Hill Honors Program