Pathology Graduate Training Program
Name: Jason M. D'Antonio
Cellular and Molecular Pathology (CMP) -
Undergraduate Degree: BA
Undergraduate Degree Year: 1997
Undergraduate Institution: University of Colorado, Boulder
Undergraduate Major: Philosophy and Environmental, Population & Organismic Biology
Academic Status: 4th Year
Graduate Program: Cellular & Molecular Pathology
Thesis Advisor: Beth R. Pflug, Ph.D.
Thesis Title/Research Topic: The Role of the Endothelin-Axis in Androgen Ablation and Progression of Advanced Prostate Cancer
Current Research Description: Hormone therapy is the primary means of treating advanced, metastatic prostate cancer. We are investigating the effects of androgen ablation on the expression of endothelin-1 and its cognate receptors, ETA & ETB. ETA is a 7TM GPC-Receptor that when bound to endothelin-1, a 21 amino acid vasoactive peptide, produces a survival signal via PI3K-to-AKT activation in prostate cancer cells. We propose that the up-regulation of the endothelin-1/ETA axis promotes prostate cancer cell survival, allowing them to endure the stress of androgen deprivation, contributing to the progression to hormone-refractory disease.
Undergraduate Honors: Phi Beta Kappa, Golden Key National Honors Society
Dean's List, Graduated with Distinction
An independent, 3-year Department of Defense predoctoral grant.
- Beth R. Pflug, Hong Zheng, Michael S. Udan, Jason M. D'Antonio, Fray F. Marshall, James D. Brooks and Joel B. Nelson. Endothelin-1 Promotes Cell Survival in Renal Cell Carcinoma through the ETA Receptor. Cancer Letters (in press). 2006.
- Nicolls MR, D'Antonio JM, Hutton JC, Gill RG, Czwornog JL, Duncan MW. Proteomics as a tool for discovery: proteins implicated in Alzheimer's disease are highly expressed in normal pancreatic islets. J Proteome Res. 2003 Mar-Apr;2(2):199-205.