Pathology Graduate Training Program
Cellular and Molecular Pathology (CMP) -
Current Graduate Students

Name: Matthew Brown
Email: mfb20@pitt.edu
Lab Phone: 412-623-3255
Mentor Name: Jian Yu, PhD

Undergraduate Education:
Undergraduate Degree: B.S. Biological Sciences, 2007
Undergraduate Institution: California State University: Sacramento

Research Project Information

Induction of alternative cell death pathways in colorectal cancer.

Publications

Brown, MF, Kan He and Jian Yu, SMAC IAP Addiction in Cancer, in Cell Death Signaling In Cancer Biology and Treatment D.E. Johnson, Editor. 2012, Springer Books: New York.

Sun, J.*, Sun, Q.*, Brown MF, Dudgeon, C., Chandler, J., Xu, X.,Shu, Y., Zhang, L and Yu, J. (2012) The multi-targeted kinase inhibitor Sunitinib induces apoptosis in colon cancer cells via PUMA. PLoS One, 2012. 7(8): p. e43158.

Brown MF, Gherman BF. Importance of iron as the metal ion in peptide deformylase: a biomimetic computational study. Theor Chem Acc. 2010, 128:137-146.

Bauer S, Parry JA, Mühlenberg T, Brown MF, Seneviratne D, Chatterjee P, Chin A, Rubin BP, Kuan SF, Fletcher JA, Duensing S, Duensing A. Pro-apoptotic activity of bortezomib in gastrointestinal stromal tumor (GIST) cells. Cancer Res. 2010, 70:150-159.

Abstracts:

Brown MF, Leibowitz B, He K, Stolz D, Sobol R, Zhang L, Yu J. Loss of caspase-3 leads to impaired growth and altered bioenergetics in colorectal cancer cells. 104th Annual Meeting of the American Association for Cancer Research, April 6-10, 2013, Washington, DC. (Poster Presentation)

Brown MF, Duensing S, Duensing A. Contributions of KIT and ABL to the therapeutic responses of GIST cells to imatinib mesylate (Gleevec ®). 101st Annual Meeting of the American Association for Cancer Research, April 17-21, 2010, Washington, DC. (Poster Presentation)

Parry JA, Brown MF, Seneviratne D, Duensing S, Duensing A. Imatinib mesylate modulates regulators of tumor cell quiescence in gastrointestinal stromal tumor cells. Connective Tissue Oncology Society (CTOS), 15th Annual Meeting, November 5-7, 2009, Miami, FL. (Oral Presentation)

2009 CMP Retreat, 2009 UPCI Retreat - "An siRNA screen of the human kinome in Gastrointestinal Stromal Tumor (GIST) cells"