Final Diagnosis -- Maturity-Onset Diabetes of the Young (MODY) -2


FINAL DIAGNOSIS:   MATURITY-ONSET DIABETES OF THE YOUNG (MODY) -2

Maturity-Onset Diabetes of the Young (MODY):

Pathogenesis in MODYs:

Distinguishing clinical characteristics between MODY and DM type 2:

MODY subtype:

MODY2 Epidemiology

GCK Gene Structure:

GCK protein and the function:

GCK mutations found in literatures

GCK mutation and phenotype:

Genetic testing indications and benefits:

REFERENCES

  1. http://www.ambrygen.com/
  2. Gloyn AL. Human Mutation, 2003, V22: 353-362.
  3. Fajans S, et al, NEJM, 2001, Volume 345:971-980.
  4. Froguel et al., Nature, 1992, 356(6365): 162-4.
  5. Hattersley et al., Lancet,1992, 339(8805): 1307-10

Contributed by Zaibo Li, MD and Jeffery Kant, MD, PhD




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