FINAL DIAGNOSIS: RECURRENT OLIGODENDROGLIOMA
1p and 19q are frequent events in gliomas and are proven to be predictors of chemotherapeutic response and prolonged survival in oligodendrogliomas. Patients with 1p/19q codeleted tumors have an overall survival of about 15 years with 4 years from first recurrence. Those without deletions had significantly lower survivals of 5 years and 12 months after first recurrence. The improved survival in patients with 1p/19q codeletion is significant when adjustments for age, tumor grade, and treatment are made . Although 1p/19q codeletions and lack of EGFR amplification with negative p53 status define "genetically favorable" oligodendrogliomas , tumor progression and recurrence remain constant .
Contributed by Simon Chiosea, MD