Microscopic Description -- Cervical Lymphadenopathy


Histologic sections demonstrated multiple, discrete, varying sized, pale staining foci distributed throughout a lymph node. These foci consisted of histiocytes, small and some transformed lymphoid cells, and abundant karyorrhectic debris. No neutrophils were identified in these areas (Images 01, 02, 03, 04, 05, 06 and 07). Follicles, some with reactive changes, prominent T-zone nodules, pigment and an interfollicular expansion were also present (Images 08 and 09).

The following immunohistochemical stains were performed:

Antigen/antibody Usual reactivity Result
LCA Leukocytes Numerous positive cells.
CD20/L26 (Image 10). B cell Highlights follicles and scattered positive cells of variable size including some very large forms, more numerous in some areas.
CD3 (Image 11) T cells Numerous positive cells
TIA 1 (Image 12) Cytolytic T cells, NK cell subset Moderate amount of positivity in areas with necrosis
CD68/PGM-1 (Image 13) Monocyte, macrophage, some lymph Moderate number of positive cells in areas of necrosis plus scattered positive cells throughout lymph node
CD15/Leu M1 (Image 14) Reed-Sternberg, myeloid Rare large cells positive, probably histiocytes
CD30/Ber H2 (Image 15) Reed-Sternberg, activated lymph Scattered positive large cells



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