Electron Microscopic Description -- Nephrotic Syndrome and Gross Hematuria


The ultrastructural findings were based on the examination of two normocellular glomeruli with non-uniform, irregular glomerular basement membrane thickening; one of the glomeruli had a segmental area of collapse with associated mild hypercellularity. The podocyte foot processes were largely discrete, with occasional patchy foot process fusion. The glomerular basement membranes exhibited prominent, irregular and discontinuous electron dense thickening (IMAGES 07A and 07B). The uninvolved glomerular basement membrane showed focal areas of thinning (IMAGE 07A). Occasional mesangial areas were expanded. No typical immune complex deposits were present. The tubular basement membranes (IMAGE 08), interstitium and a peritubular capillary (IMAGE 09) contained focal electron dense material similar to that present within the dense deposits of the glomerular basement membrane.



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