Microscopic Description -- A Left Breast Mass


Microscopic examination (Images 06, 07 and 08) reveals an invasive proliferation of circumscribed nests, islands, and clusters of tumor cells forming cribriform, tubular, and fewer solid arrangements. There is a predominant population of basaloid cells with a smaller population of cells having bright eosinophilic cytoplasm. Within the spaces formed by the cribriform cell arrangements, there is a mucoid secretory material. In other areas, there is a bright eosinophilic band deposited on the cells lining these spaces. Mucicarmine (Image 09) and alcian blue (Image 10) stains were positive. Immunohistochemical studies revealed the neoplastic cells to be positive for cytokeratin (AE1/AE3) (Image 11), epithelial membrane antigen (Image 12), and carcinoembryonic antigen (Image 13). Vimentin and Cam5.2 immunostains were noncontributory.



IndexCME Case StudiesFeedbackHome