Contributed by Armen Kasyan, MD, John M. Skaugen, MD
Contributed by Armen Kasyan, MD, John M. Skaugen, MD
PATIENT HISTORY
A male patient in his 60s with a history of urothelial carcinoma metastatic to the liver, status post radical cystoprostatectomy and chemotherapy. Patient later presented with right renal pelvis tumor. The biopsy showed fragments of high grade urothelial carcinoma with inverted growth pattern, with tumor cells positive for uroplakin II + III, CAM 5.2, and GATA-3 by immunohistochemical analysis. Patient was treated with gemcitabine, carboplatin and Enfortumab but progressed, with evidence of new lung and liver metastases. Oncomine NGS testing was performed to identify potential therapeutic targets.
SUMMARY OF MOLECULAR FINDINGS
DNA Mutations
