MICROSCOPIC DESCRIPTION:
The hematoxylin and eosin slide shows a poorly differentiated malignant neoplasm with some suggestion of rosette formation. No necrosis and rare mitoses are seen. The cells are primitive with high nuclear to cytoplasmic ratios, round to oval nuclei with inconspicuous nucleoli and scant, clear cytoplasm. An immunohistochemical panel included cytokeratin, leukocyte common antigen, vimentin and 12E7(MIC2). Cytokeratin, leukocyte common antigen and vimentin were negative, but the 12E7 demonstrated the characteristic membranous positivity in the neoplastic cells.
