Jianhui Zhu, MD, PhD
Research Assistant Professor of Pathology
Dr. Zhu is a member of the Division of Experimental Pathology.
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Office Location: A518 Scaife Hall Department of Pathology 200 Lothrop Street Pittsburgh, PA 15261 |
Contact Information: Office Telephone: 412-648-8315 Lab Telephone: 412-383-5380 Email: jiz19@pitt.edu |
Education
- M.Med. - 1990, Shanghai Medical University
- PhD - 2000, The Chinese University of Hong Kong
Research Interests
Research interests include: 1. the role of intracellular signaling pathways, in particular, MEK-ERK pathway on regulation of mitochondrial biogenesis and dynamics in Parkinsonian neurotoxin, MPP+ models; 2.involvement of autophagy-lysosome dysfunction in the pathogenesis of neurotoxic and genetic models of Parkinson’s disease.Selected Publications
View Dr. Zhu's publications on PubMed
- Zhu JH and Chu C (2010) Mitochondrial dysfunction in Parkinson’s disease: J Alzheimer's Dis. 20: S325-S334
- Hu XM, Weng ZF, Chu CT, Zhang LL, Cao GD, GaoYQ, Signore A, Zhu JH, Hastings T, Greenamy JT and Chen J (2011) Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the ASK1 signaling cascade. J Neurosci. 5;31(1):247-61
- Zhu JH, Dagda RK and Chu CT (2011) Monitoring mitophagy in neuronal cell cultures. Methods in Mol Biol. 793: 325-39
- Gusdon AM, Zhu JH, Van Houten B, Chu CT (2012) ATP13A2 regulates mitochondrial bioenergetics through macroautophagy, Neurobiol. Dis, doi:10.1016/j.nbd.2011.12.015.
- Zhu JH, Gusdon AM, Cimen H, Van Houten B, Koc E, Chu CT (2012) Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP+ toxicity: dual roles for ERK1/2. Cell Death & Disease. doi: 10.1038/cddis.2012.46