Yan Ping Yu, MD, PhD
Assistant Professor of Pathology
Dr. Yu is a member of the Division of Experimental Pathology.
Rm. BST S423
University of Pittsburgh
Pittsburgh. PA 15261
Office Telephone: 412-648-0231
Research InterestsDr. Yu's research interests focus on the analysis of genomic instability in prostate cancer, the identification of key genetic abnormalities and their phenotypes in cancer. We particularly like to know how these genetic events regulate the initiation of cancer cell transformation and the tumor malignancy. To attain these aims, we utilize high throughput analysis of gene expression, genome structure, DNA methylation in our studies. We then characterize the genetic events identified from above analysis with a variety of biological methods, including mouse model. Current ongoing research includes two parts: 1) To characterize the tumor suppression of GPx3 and its therapeutic value in prostate cancer. GPx3 gene is found deleted in a small number of prostate cancers and methylated in most of prostate cancers. We are intrigued by the translational needs of GPx3 for selenium, which at low level in population is found correlated with high incidences of prostate cancers. But we still don't know how importance of down-regulation of GPx3 in tumorigenesis; 2) To characterize the instabilities of prostate cancer genome and abnormal epigenetics of the disease. The genome copy number aberrations, unique methylations and their concordant gene expression events and phenotype analysis of these findings will be investigated.
Dr. Yu is an associate director of High Throughput Genome Center.
Selected PublicationsView Dr. Yu's publications on PubMed
Yan-Ping Yu and Jian-Hua Luo (2011). Phosphorylation and interaction of Myopodin by Integrin-Link Kinase Lead to Suppression of Cell Growth and Motility in Prostate Cancer Cells. Oncogene 30, 4855-63.
Yi-Kang Shi, Yan P. Yu, George C. Tseng and Jian-Hua Luo (2010). Inhibition of prostate cancer growth and metastasis using small interference RNA specific for minichromosome complex maintenance component 7. Cancer Gene Therapy 17, 694-699.
Ze-Hua Zhu, Yan P. Yu, Zhong-Liang Zheng, Yang Song, Guo-Sheng Xiang, Joel Nelson1, George Michalopoulos and Jian-Hua Luo (2010). Integrin alpha 7 interacts with HtrA2 to induce prostate cancer cell death. American Journal of Pathology, Am J Pathol. 2010 Sep;177(3):1176-86. Epub 2010 Jul 22.
Yu-Chen Han, Yan P. Yu, Joel Nelson, Chuanyue Wu, Hui Wang, George K. Michalopoulos and Jian-Hua Luo (2010). Interaction of integrin-linked kinase (ILK) and MCM7-mediating integrin α7 induced cell growth suppression. Cancer Res. 2010 Jun 1;70(11):4375-84. Epub 2010 May 11.
Luo, KL, Luo, JH, Yu,YP (2010). (-)-Epigallocatechin-3-gallate inducing Du145 prostate cancer cell death via down regulation of Inhibitor of DNA binding 2, a dominant negative helix-loop-helix protein. Cancer Sci. 2010 Mar;101(3):707-12. Epub 2009 Nov 6.
Yu-Chen Han, Yan P. Yu, George C. Tseng and Jian-Hua Luo (2009). Trypsin and Reduction Method to Prepare DNA from Formalin-Fixed and Paraffin Embedded Samples for Methylation Analysis. Histopathology, 54:773-5.
George C. Tseng, Chunrong Cheng, Yan Ping Yu, Joel Nelson, George Michalopoulos and Jian-Hua Luo (2009). Common Predictive Biomarkers and Cross-predictability in the Expression Profiles of Multiple Cancer Types. Biomarker Insights 4, 57-79.
Yi-Kang Shi, Yan P. Yu, Ze-Hua Zhu, Yu-Chen Han, Baoguo Ren, Joel B. Nelson and Jian-Hua Luo (2008). MCM7 Interacting With Androgen Receptor. American Journal of Pathology, 173:1758-67.
Ze-Hua Zhu, Yan P. Yu, Yi-Kang Shi, Joel B. Nelson, and Jian-Hua Luo (2009). CSR1 Inducing Cell Death through Inactivation of CPSF3. Oncogene 28:41-51.
Yan Ping Yu and Jian-Hua Luo (2008). Myopodin. Encyclopedia of Cancer, 2nd Edition, Springer-Verlag GmbH, Berlin, Heidelberg.
Vasiliki Gkretsi, Udayan Apte, Wendy M. Mars, William C. Bowen1, Jian-Hua Luo, Yu Yang, Yan P.Yu, Ann Orr, René St.-Arnaud, Shoukat Dedhar, Klaus H. Kaestner, Chuanyue Wu and George K. Michalopoulos (2008). Liver specific ablation of integrin linked kinase in mice results in abnormal histology, enhanced cell proliferation and hepatomegaly. Hepatology 48:1932-41.
Yu, Y.P., Yu G, Tseng G, Cieply K, Nelson J, DeFrances M, Zarnegar R, Michalopoulos G, Luo JH. (2007). Glutathione peroxidase 3, deleted or methylated in prostate cancer, suppresses prostate cancer growth and metastasis. Cancer Res.67(17):8043-50.