Mark H. Yazer, MD
Associate Professor of Pathology

Dr. Yazer is a member of the Institute for Transfusion Medicine.

Office Location:
Institute for Transfusion Medicine
3636 Blvd. of the Allies
Pittsburgh, PA 15213
Contact Information:
Office Telephone: 412-209-7522
Fax: 412-209-7485
Email: myazer@ixtm.org

Education

  • MD - University of Ottawa, 2000

Research Interests

Dr. Yazer's main research focus is in the area of blood group genetics, specifically the ABO blood group system. Using molecular techniques the nature of the alleles underlying weak A and B phenotypes can be elucidated and the resulting enzyme expressed in a bacterial model to facilitate studying its reaction kinetics. These studies provide insights into fundamental questions of glycobiology and enzyme kinetics. Dr. Yazer is also actively involved in studying the coagulation effects of xenotransplantation.

Certifications

Hematological Pathology, Royal College of Physicians and Surgeons of Canada - 2004

Awards and Honors

  • Nominated for University of Pittsburgh Clinical Pathology Faculty of the Year - 2008-10
  • University of Pittsburgh Clinical Pathology Faculty of the Year - 2006

Selected Publications

View Dr. Yazer's publications on PubMed

SK Harm, M Delaney, M Charapata, JP AuBuchon, DJ Triulzi, MH Yazer. Routine use of a rapid test to detect bacteria at the time of issue for non-leukoreduced, whole blood-derived platelets. Transfusion, in press.

Harm SK, Waters JH, Yazer MH. Changes in Hematologic Indices in Caucasian and Non-Caucasian Pregnant Women in the United States. Korean J Hematology, in press.

L Radkay, DJ Triulzi, MH Yazer. Low risk of hemolysis following transfusion of uncrossmatched RBCs. Immunohematology, in press.

SK Harm, JH Waters, P Lynn, R Dyga, JS Raval, RF DiMarco, MH Yazer. Changes in mechanical fragility and free hemoglobin levels after processing salvaged cardiopulmonary bypass circuit blood with a modified ultrafiltration device. The Journal of Extracorporeal Technology 2012;44:21-25.

JH Waters, MH Yazer, Y-F Chen, J Kloke. Blood Salvage and cancer surgery: A meta-analysis of available studies. Transfusion in press.

B McWilliams, MH Yazer,* J Cramer, DJ Triulzi, and JH Waters. Incomplete pre-transfusion testing leads to surgical delays. Transfusion in press. *Co-first author

Harm SK, Raval JS, Cramer J, Waters JH, Yazer MH. Hemolysis and sublethal injury of RBCs after routine blood bank manipulations. Transfusion Medicine 2012;22:181-185.

Yazer MH, Raval JS, Triulzi DJ, Blumberg N. ABO mismatched transfusions are not over represented in febrile reactions to platelets. Vox Sanguinis 2012;102:175-177.

Feingold B, Raval JS, Galambos C, Yazer MH, Wearden P, Morell V. Tolerance to incompatible ABO blood group antigens is not observed following homograft implantation. Human Immunology 201;72:835-840.

Narick C, Triulzi DJ, Yazer MH. Transfusion Associated Circulatory Overload Following Plasma Transfusion. Transfusion 2012;52:160-165.

Lee JS, Donahoe M, Yazer MH, Woodske M. Acute exacerbation of subclinical pulmonary fibrosis following red cell transfusion: a case report. Transfusion 2012;52:589-594.

X Jin, MH Yazer, JJ Chalmers, M Zborowski. Quantification of changes in oxygen release from red blood cells as a function of age based on magnetic susceptibility measurements. Analyst 2011;136:2996-3003.

Ley T, Yazer MH, Waters JH. Hemolysis and red blood cell mechanical fragility in shed blood following total knee arthroplasty. Transfusion 2012;52:34-38.

Raval JS, Waters JH, and Yazer MH. The impact of suctioning RBCs from a simulated operative site on mechanical fragility and hemolysis. The Korean Journal of Hematology 2011;46:31-35.

Waters JH, Dyga RM, and Yazer MH. The volume of returned RBCs in a large blood salvage program: Where does it all go? Transfusion 2011;51:2126-2132.

D-W Kim, D Cho, MH Yazer, H-J Lee, KH Kim, M-G Shin, SP Suh, J-H Shin, D-W Ryang. A novel A subtype allele that demonstrates allelic competition. Annals of Clinical and Laboratory Science 2011;41:282-284.

JS Raval, JH Waters, A Seltsam, EA Scharberg, E Richter, MV Kameneva, MH Yazer. Menopausal status affects the susceptibility of stored RBCs to mechanical stress. Vox Sanguinis 2011;100:418-421.

JS Raval, JH Waters, A Seltsam, EA Scharberg, E Richter, MV Kameneva, MH Yazer. The use of the mechanical fragility test in evaluating sublethal RBC injury during storage. Vox Sanguinis 2010;99:325-331.

Ekser B, Echeverri G, Cortese Hassett A, Yazer MH, Meyer M, Ezzelerab M, Lin CC, Hara H, van der Windt D, Dons E, Phelps C, Ayares D, Cooper DKC, and Gridelli B. Hepatic function after genetically engineered liver transplantation in baboons. Transplantation 2010;90:483-493.