Chuanyue Wu, PhD
Professor of Pathology
Dr. Wu, Professor of Pathology and Lombardi and Shinozuka Experimental Pathology Research Chair, is a member of the Section of Laboratory Medicine.
S-707B Scaife Hall
University of Pittsburgh
3550 Terrace Street
Pittsburgh, PA 15261
Office Telephone: 412-648-2350
Lab Telephone: (412) 624-2471
- PhD - University of Pittsburgh, 1990
Awards and Honors
- 2011 - Pitt Innovator Award, University of Pittsburgh
- 2010 - Pitt Innovator Award, University of Pittsburgh
- 1998 - V Foundation Scholar, V Foundation for Cancer Research
- 1996 - Edward Livingston Trudeau Scholar, American Lung Association
- 1996 - Parker B. Francis Fellow
- 1996 - Edward C. Kendall Alumni Award for Meritorious Research, Mayo Foundation
Cell-extracellular matrix adhesion is a fundamental process that regulates cell shape, proliferation and differentiation. Abnormalities in cell-matrix adhesion and extracellular matrix assembly are closely associated with the pathogenesis of a variety of human diseases. The goals of my research are:
- To elucidate the molecular mechanism underlying cell-extracellular matrix adhesion and signaling
- To determine the role of integrin-linked kinase signaling in the pathogenesis of diabetic nephropathy
To achieve these goals, we are employing a wide variety of molecular and cell biological techniques including molecular cloning, mutagenesis, gene transfer, protein expression, yeast two-hybrid and other protein-protein interaction assays, hybridoma production, cell culture, cell adhesion, cell migration, immunofluorescence microscopy, immunoprecipitation, Northern, Southern and Western blotting, cell proliferation, apoptosis, and immunohistochemistry in our research. We have demonstrated that a protein complex consisting of PINCH-1, integrin-linked kinase (ILK) and parvin is crucial for cell-matrix adhesion, migration and survival signaling. Alterations of the PINCH-1-ILK-parvin complex are involved in the pathogenesis of diabetic nephropathy. Furthermore, we have identified a critical role of kindlin-2 in regulation of integrin activation and cell-matrix adhesion. Our studies shed new light on the molecular basis underlying cell-matrix and cell-cell communications as well as their roles in the pathogenesis of human diseases including diabetic nephropathy and cancer.
NIH ResearchView Dr. Wu's NIH RePORT on nih.gov
Selected PublicationsView Dr. Wu's publications on PubMed
- Wu, C., Jiao, H., Lai, Y., Zheng, W., Chen, K., Qu, H., Deng, W., Song, P., Zhu, K., Cao, H., Galson, D.L., Fan, J., Im, H.J., Liu, Y., Chen, J., Chen, D., Xiao, G.. Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesis. Nature Communications. (2015) 6:7531. doi: 10.1038/ncomms8531. PMCID: PMC4498276.
- Cui, X.B., Wang, D.D., Zhang, H.Y., Li, T.T., Jin, T.T., Peng, H., Zhang, S.M., Wang, B., Yu, J., Liu, C.X., Yang, L., Jin, J., Li, S., Jiang, J.F., Liang, W.H., Hu, J.M., Li, S.G., Wu, C.Y., Chen, Y.Z., Li, F. Tumor necrosis factor-α gene 308G/A polymorphism is not associated with esophageal squamous cell carcinoma risk in Kazakh patients. Int J Clin Exp Pathol. (2015) 8(8):9293-9. eCollection 2015. PMCID: PMC4583911.
- Cui, X.B., Shen, Y.Y., Jin, T.T., Li, S., Li, T.T., Zhang, S.M., Peng, H., Liu, C.X., Li, S.G., Yang, L., Li, N., Hu, J.M., Jiang, J.F., Li, M., Liang, W.H., Li, Y., Wei, Y.T., Sun, Z.Z., Wu, C.Y., Chen, Y.Z., Li, F. SLC39A6: a potential target for diagnosis and therapy of esophageal carcinoma. J Transl Med. (2015) 13:321. doi: 10.1186/s12967-015-0681-z. PMCID: PMC4595240.
- Cui, X.B., Li, S., Li, T.T., Peng, H., Jin, T.T., Zhang, S.M., Liu, C.X., Yang, L., Shen, Y.Y., Li, S.G., Li, N., Li, Y., Hu, J.M., Jiang, J.F., Suo, J., Qi, Y., Liang, W.H., Wang, L.H., Dang, H.W., Li, L., Cao, W.W., Wei, Y., Yin, L., Wu, C., Yuan, X.L., Zhou, H., Zheng, Y., Chen, Y.Z., Li, F. Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma. Oncotarget. (2016) 7(2):1777-95. doi: 10.18632/oncotarget.6499. PMCID: PMC4811497.
- Kim, S.Y., Hong, S.H., Basse, P.H., Wu, C., Bartlett, D.L., Kwon, Y.T., Lee, Y.J. Cancer Stem Cells Protect Non-Stem Cells from Anoikis: Bystander Effects. J Cell Biochem. (2016) 117(10):2289-301
- Wu, C., You, J., Fu, J., Wang, X,, Zhang, Y. Phosphatidylinositol 3-Kinase/Akt Mediates Integrin Signaling To Control RNA Polymerase I Transcriptional Activity. Mol Cell Biol. (2016) 36(10):1555-68. doi: 10.1128/MCB.00004-16. Print 2016 May 15. PMCID: PMC4859695
- Huang, T., Liu, R., Fu, X., Yao, D., Yang, M., Liu, Q., Lu, W.W., Wu, C., Guan, M. Aging reduces an ERRalpha-directed mitochondrial glutaminase expression suppressing glutamine anaplerosis and osteogenic differentiation of mesenchymal stem cells. Stem Cells. 2016 Aug 9. doi: 10.1002/stem.2470. [Epub ahead of print]