Lisa J. Robinson, MD
Associate Professor of Pathology

Dr. Robinson

Dr. Robinson is a member of the Division of Hematopathology and Cellular and the Molecular Pathology Graduate Training Program.

Office Location:
Rm. S-707A Scaife Hall
University of Pittsburgh
Pittsburgh, PA 15261
Contact Information:
Office Telephone: 412-647-0365
Fax: 412-647-6332
Email: robinsonlj@upmc.edu

Education

  • MD - Cornell University, 1991

Clinical Expertise

  • Diagnostic hematopathology including development and application of molecular testing for hematologic malignancies
  • Evaluation of bone and bone marrow in metabolic and congenital bone disease

Research Interests

  • Signal transduction mechanisms regulating myelopoiesis and their perturbation in myeloid neoplasms
  • Molecular mechanisms of regulatory interactions between hematopoietic cells and bone marrow stroma
  • Mouse histopathology for the analysis of bone and bone marrow/hematologic disorders in transgenic mice, including application of flow cytometry, immunohistochemistry and bone histomorphometry (including micro-computed tomography)

Certifications

Anatomic Pathology/Clinical Pathology (American Board of Pathology), 2001

Specialties

Pathology and Hematopathology

Selected Publications

View Dr. Robinson's publications on PubMed

Robinson LJ, Mancarella S, Songsawad S, Tourkova IL, Barnett JB, Gill DL, Soboloff J, Blair HC. Gene disruption of the calcium channel Orai1 results in inhibition of osteoclast and osteoblast differentiation and impairs skeletal development. Laboratory Investigation, in press.

Zhou Y, Lewis TL, Robinson LJ, Brundage KM, Schafer R, Martin KH, Blair HC, Soboloff J, Barnett JB. The role of calcium release activated calcium channels in osteoclast differentiation. J Cell Physiol. 2011; 226:1082-9.

Robinson LJ, Tourkova I, Wang Y, Sharrow AC, Landau MS, Yaroslavskiy BB, Sun L, Zaidi M, Blair HC. FSH-receptor isoforms and FSH-dependent gene transcription in human monocytes and osteoclasts. Biochem Biophys Res Commun. 2010; 394:12-7.

Zaidi M, Sun L, Robinson LJ, Tourkova IL, Liu L, Wang Y, Zhu LL, Liu X, Li J, Peng Y, Yang G, Shi X, Levine A, Iqbal J, Yaroslavskiy BB, Isales C, Blair HC. ACTH protects against glucocorticoid-induced osteonecrosis of bone. Proc Natl Acad Sci USA. 2010;107:8782-7.

Robinson LJ, Blair HC, Barnett JB, Zaidi M, Huang CL. Regulation of bone turnover by calcium-regulated calcium channels. Ann N Y Acad Sci. 2010; 1192:351-7.

Yaroslavskiy BB, Turkova I, Wang Y, Robinson LJ*, Blair HC*. Functional osteoclast attachment requires inositol-1,4,5-trisphosphate receptor-associated cGMP-dependent kinase substrate. Lab Invest. 2010;90:1533-42. *co-senior authors

Mistry PK, Liu J, Yang M, Nottoli T, McGrath J, Jain D, Zhang K, Keutzer J, Chuang WL, Mehal WZ, Zhao H, Lin A, Mane S, Liu X, Peng YZ, Li JH, Agrawal M, Zhu LL, Blair HC, Robinson LJ, Iqbal J, Sun L, Zaidi M. Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage. Proc Natl Acad Sci U S A. 2010;107:19473-8.

Wittschieben JP, Patil V, Glushets V, Robinson LJ, Kusewitt DF, Wood RD. Loss of DNA polymerase zeta enhances spontaneous tumorigenesis. Cancer Res. 2010;70:2770-8.

Robinson LJ, Yaroslavskiy BB, Griswold RD, Zadorozny EV, Guo L, Tourkova IL, Blair HC. Estrogen inhibits RANKL-stimulated osteoclastic differentiation of human monocytes through estrogen and RANKL-regulated interaction of estrogen receptor-alpha with BCAR1 and Traf6. Exp Cell Res. 2009;315:1287-301.

Wang L, Xue J, Zadorozny EV, Robinson LJ. G-CSF stimulates Jak2-dependent Gab2 phosphorylation leading to Erk1/2 activation and cell proliferation. Cell Signal. 2008;20:1890-9.