Jennifer Picarsic, MD
Assistant Professor of Pathology


Dr. Jennifer Picarsic is a board certified Pediatric Pathologist at the Children's Hospital of Pittsburgh of UPMC and Assistant Professor at the University of Pittsburgh School of Medicine in the Department of Pathology. Dr. Picarsic joined on as faculty after completing her residency training in Anatomic and Clinical Pathology in 2011 at UPMC and her Pediatric Pathology Fellowship at Children's Hospital of Pittsburgh in 2012. Dr. Picarsic's academic interests are in the fields of histiocytic disorders, heart transplant pathology, and informatics, improving trainee educations, and pediatric molecular pathology. Dr. Picarsic serves as the Director of Pathology Informatics at Children's Hospital of Pittsburgh. Follow her on Twitter @jpcrsc.

Office Location:
Children's Hospital of Pittsburgh
B260
One Children's Hospital Drive
4401 Penn Ave.
Pittsburgh, PA 15224
Contact Information:
Office Telephone: 412-692-5650
Fax: 412-692-6550
Email: picarsicj@upmc.edu

Education

  • MD - University of Pittsburgh, 2007
  • BS - Dickinson College, summa cum laude, 2003

Clinical Expertise

General diagnostic pediatric pathology with a special interest in:
  • Childhood histiocytoses
  • Pediatric transplantation pathology
  • Pathology informatics

Research Interests

Dr. Picarsic's main academic interest is centered around the pathobiology of histiocytic neoplasms, a rare group of white blood cell disorders that affects both pediatric and adult patients. She leads a busy histiocytic consult service with regional, national, and international case referrals. She has authored numerous manuscripts, abstracts, book chapters, and invited reviews on the topic. She is the North American pathology study reviewer for the International Rare Histiocytic Disorders Registry (IRHDR), which is sponsored by the Histiocyte Society, the international multidisciplinary scientific group on this rare group of disorders. She also serves on both the Scientific Committee and Rare Histiocytic Disorders Committee for the Histiocyte Society. Dr. Picarsic is also involved in a number of collaborative histiocytic research projects with other academic experts in the field. In addition to her diagnostic work on pediatric transplant pathology, Dr. Picarsic has also participated in studies investigating post-transplant lymphoproliferative disorders (PTLD) along with a recent study correlating clinical parameters and outcomes with markers of end-stage fibrosis in pediatric heart transplant patients using novel digital pathology techniques, in collaboration with Dr. Demetris and Dr. Feingold.

Certifications

  • Diplomat of the American Board of Pathology
  • American Board of Pathology, Combined Anatomic and Clinical Pathology
  • American Board of Pediatric Pathology

Specialties

  • Pediatric Pathology

Awards and Honors

  • American Society of Clinical Pathology (ASCP) Forty under 40 honoree
  • American Society of Clinical Pathology (ASCP) Award for Academic Excellence
  • UPSOM, Robert E. Lee Award for Excellence in Anatomic Pathology
  • Phi Beta Kappa

Selected Publications

View Dr. Picarsic's publications on PubMed
  1. Feingold B, Picarsic J, Lesniak A, Popp BA, Wood-Trageser MA, Demetris AJ. Late graft dysfunction after pediatric heart transplantation is associated with fibrosis and microvasculopathy by automated, digital whole-slide analysis. J Heart Lung Transplant. 2017;36:1336-43. (PMID: 29055602).
  2. Liang J, Alfano DN, Squires JE, Riley MM, Parks WT, Kofler J, El-Gharbawy A, Madan-Kheterpal S, Acquaro R, Picarsic J. Novel NLRC4 Mutation Causes a Syndrome of Perinatal Autoinflammation with Hemophagocytic Lymphohistiocytosis, Hepatosplenomegaly, Fetal Thrombotic Vasculopathy, and Congenital Anemia and Ascites. Pediatr Dev Pathol. Nov-Dec;20(6):498-505. (PMID: 28403691).
  3. Picarsic J, Jaffe R. Nosology and Pathology of Langerhans Cell Histiocytosis. Hematol Oncol Clin North Am. 2015 Oct;29(5):799-823.(PMID: 26461144).
  4. Gibson SE, Picarsic J, Swerdlow SH, Pantanowitz L. Role of Epstein-Barr virus status and immunophenotypic studies in the evaluation of exfoliative cytology specimens from patients with post-transplant lymphoproliferative disorders. Cancer Cytopathol. 2016 Jun;124(6):425-35.(PMID: 26992116).
  5. Emile JF, Abla O, Fraitag S, Horne A, Haroche J, Donadieu J, Requena-Caballero L, Jordan MB, Abdel-Wahab O, Allen CE, Charlotte F, Diamond EL, Egeler RM, Fischer A, Herrera JG, Henter JI, Janku F, Merad M, Picarsic J, Rodriguez-Galindo C, Rollins BJ, Tazi A, Vassallo R, Weiss LM; Histiocyte Society.. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood. 2016 Jun 2;127(22):2672-81. (PMID: 26966089).
  6. Gomez-Ospina N, Potter CJ, Xiao R, Manickam K, Kim MS, Kim KH, Shneider BL, Picarsic JL, Jacobson TA, Zhang J, He W, Liu P, Knisely AS, Finegold MJ, Muzny DM, Boerwinkle E, Lupski JR, Plon SE, Gibbs RA, Eng CM, Yang Y, Washington GC, Porteus MH, Berquist WE, Kambham N, Singh RJ, Xia F, Enns GM, Moore DD. Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis. Nat Commun. 2016 Feb 18;7:10713. (PMID: 26888176).
  7. Picarsic J, Buryk MA, Ozolek JA, Ranganathan S, Monaco SE, Simons JP, Witchel S Gurtunca N, Joyce J, Zhong S, Nikiforova MN, Nikiforov Y. Molecular characterization of sporadic pediatric thyroid carcinoma with the DNA/RNA ThyroSeq v2 next-generation sequencing assay. Pediatr Dev Pathol. 2016 Mar-Apr;19(2):115-22. (PMID: 26367451).
  8. Johnson WT, Patel P, Hernandez A, Grandinetti LM, Huen AC, Marks S, Ho J, Monaco SE, Jaffe R, Picarsic J. Langerhans Cell Histiocytosis and Erdheim-Chester Disease, both with cutaneous presentations, and papillary thyroid carcinoma all harboring the BRAF(V600E) Mutation. J Cutan Pathol. 2016 Mar;43(3):270-5 (PMID: 26454140).
  9. Buryk M, Picarsic J, Creary SE, Shaw PH, Simons JP, Deutsch M, Monaco SE, Nikiforov Y, Witchel S. Identification of unique heterozygous germline mutation, STK11 (p.F354L), in a child with encapsulated follicular variant of papillary thyroid carcinoma within 6 months of completing treatment for neuroblastoma. Pediatr Dev Pathol. 2015 Mar 9. [Epub ahead of print]. (PMID: 25751324).
  10. Picarsic J, Egeler RM, Kudakwashe C, Patterson K, Jaffe R. Histologic patterns of thymic involvement in Langerhans cell proliferations: a clinicopathologic study and review of the literature. Pediatr Dev Pathol. 2015 Mar-Apr;18(2):127-38. (PMID: 25629953).
  11. Picarsic J, Jaffe R, Mazariegos G, Webber SA, Ellis D, Green MD, Reyes-M˙gica M. Post-transplant Burkitt lymphoma is a more aggressive and distinct form of post-transplant lymphoproliferative disorder. Cancer. 2011;117:4540-4550. (PMID: 21446044)
  12. Picarsic J, Raval JS, Macpherson. United States Medical Licensing Exam Step 1 two-digit score-a correlation with the American Board of Pathology first-time taker pass/fail rate at the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Arch Pathol Lab Med. 2011:135(10):1349-52. (PMID: 21970491)

Published Book Chapters:

  1. Picarsic J., Jaffe R. (2018) Pathology of Histiocytic Disorders and Neoplasms and Related Disorders: 3-50. In: Histiocytic Disorders, Abla O., Janka G. (eds). Springer, Cham.
  2. Abla O., Picarsic J. (2018) Rosai-Dorfman Disease: 339-360. In: Histiocytic Disorders, by Abla O., Janka G. (eds). Springer, Cham.
  3. Minkov M., Picarsic J., Lakatos K. (2018) Central Nervous System Langerhans Cell Histiocytosis: 87-101. In: Histiocytic Disorders, by Abla O, Janka G. (eds). Springer, Cham.
  4. Picarsic J. Chikwava K. (2017) Disorders of Histiocytes. In Hematopathology, 3rd edition by Hsi E (eds). Elsevier. Foundations in Diagnostic Pathology Series.
  5. Picarsic J, Nikiforova M, Reyes-M˙gica (2013). Molecular Diagnostics of Pediatric Tumors. In Principles of Molecular Diagnostics and Personalized Cancer Medicine, by Dongfeng Tan, MD and Henry Lynch, MD (eds): Lippincott Williams & Wilkins.