Tim D. Oury, MD, PhD
Professor of Pathology
Dr. Oury is a member of the Division of Molecular Genomic Pathology.
Dr. Oury is co-director of a program designed to transition physician scientist trainees into academic faculty professorships. This combined Residency-Post-doctoral Research Fellowship or combined Residency-PhD program is designed to develop Academic Pathologists to become independent Principal Investigators and to play a leading role in combined research and diagnostic careers.
200 Lothrop Street
Pittsburgh, PA 15261
Office Telephone: 412-648-8519
Lab Telephone: 412-648-9659
- PhD - Duke University, 1993
- MD - Duke University, 1994
Clinical ExpertiseMolecular Diagnostics
Research ExpertiseDr. Oury's laboratory is investigating the role of reactive oxygen species in pulmonary disease and innate immunity. His laboratory is particularly focused on how oxidative modification of components of the extracellular matrix contribute to inflammatory responses and pulmonary fibrosis and how the enzyme extracellular superoxide dismutase (EC-SOD) modulates these responses.
In addition, recent studies from the laboratory of Dr. Oury found that EC-SOD plays an important role in innate immunity. The laboratory found that EC-SOD located in granules within phagocytic inflammatory cells is essential for bacterial phagocytosis. The laboratory is now investigating mechanisms in which EC-SOD is regulating bacterial phagocytosis and if EC-SOD may be useful as an adjuvant therapy for treating bacterial infections such as pneumonia.
Finally, Dr. Oury is investigating a novel role for the receptor for advanced glycation endproducts (RAGE) in interstitial lung disease and asthma. Findings suggest that RAGE is very important in the pathogenesis of asthma and that blocking RAGE signaling with a soluble decoy receptor sRAGE can protect against allergic airway inflammation.
Selected Publications:View Dr. Oury's publications on PubMed.
Kliment CR, Clemens K, Oury TD. (2009) North American erionite-associated mesothelioma with pleural plaques and pulmonary fibrosis. A case report. Int. J. Clin. Exper. Path.2: 407-410. PMCID: PMC2615598.
Kliment CR, Englert JM, Gochuico B, Yu G, Kaminski N, Rosas I, Oury TD. (2009) Oxidative Stress Alters Syndecan-1 Distribution in the Lung During Pulmonary Fibrosis. J. Biol. Chem. 284: 3537-45. PMCID: PMC2635035
Ganguly K, Depner M, Fattman C, Bein K, Oury TD, Wesselkamper SC, Borchers MT, Schreiber M, Gao F, von Mutius E, Kabesch M, Leikauf GD, Schulz H. (2009) Superoxide dismutase 3, extracellular (SOD3) variants and lung function, Physiol Genomics. 37:260-267
Voeghtly L, Thogersen I, Chu C, Oury TD, Enghild J. (2009) Biosynthesis and plasma elimination of mature prostate specific antigen and its activation peptide. Int. J. Clin. Exper. Path. 2: 588-98.
Ghio AJ, Tan RT, Ghio K, Fattman CL, Oury TD. (2009) Iron accumulation and expression of iron-related proteins following in vivo exposure to crocidolite. J. Env. Path. Tox. Onc. 28: 153-62
Kliment CR, Suliman HB, Tobolewski JM, Reynolds CM, McTiernan CF, McGaffin KR, Piantadosi CA, Oury TD. (2009) Extracellular Superoxide Dismutase Regulates Cardiac Function and Fibrosis. J. Mol. Cell. Cardiol. 47: 730-742. PMCID: PMC2774793.
Ramsgaard L, Englert JM, Tobolewski J, Tomai L, Fattman CL, Leme AS, Kaynar MA, Shapiro SD, Enghild JJ, Oury TD. (2010) The role of the receptor for advanced glycation end-products in a murine model of silicosis. PLoS ONE 5(3): e9604. doi: 10.1371/journal.pone.0009604. PMCID: PMC2841632
Kliment CR and Oury TD. (2010) Oxidative Stress, Extracellular Matrix Targets and Idiopathic Pulmonary Fibrosis. Free Rad Biol Med. 49: 707-17. PMID: 20452419
Petersen SV, Thogersen IB, Valnickova Z, Nielsen MS, Petersen JS, Poulsen ET, Jacobsen C, Oury TD, Moestrup SK, Crapo JD, Nielsen NC, Kristensen T, Enghild JJ. (2010) The concentration of extracellular superoxide dismutase in plasma is maintained by LRP-mediated endocytosis, Free Radic Biol Med 49: 894-899. PMID: 20600835
Pociask DA, Oury TD, Steele C, Kolls JK. (2011) Gamma Delta T Cells Attenuate Bleomycin Induced Fibrosis Through the Production of CXCL10. Am. J. Pathol. 178: 1167-76. PMCID: PMC3070585
Manni ML, Tomai LP, Norris CA, Thomas M, Kelley EE, Salter RD, Crapo JD, Chang LY, Watkins SC, Piganelli JD, Oury TD. (2011) Extracellular superoxide dismutase attenuates bacterial pneumonia by modulating phagocytosis. Am. J. Pathol. 178: 2752-9. PMCID: PMC3124355 [Available on 2012/6/1]
Kliment CR and Oury TD. (2011) Extracellular superoxide dismutase protects cardiovascular syndecan-1 from oxidative shedding. Free Rad Biol Med. 50: 1075-80. PMCID: PMC3070856 [Available on 2012/5/1]
Brown B, Price I, Toapanta FR, DeAlmeida DR, Wiley CA, Ross TM, Oury TD, Vodovotz Y. (2011) An agent-based model of inflammation and fibrosis following particulate exposure in the lung. Mathematical Biosciences. 231: 186-96. PMC3088650
Englert JM, Kliment CR, Ramsgaard L, Tobolewski JM, Oury TD. (2011) Paradoxical function for the receptor for advanced glycation endproducts in models of pulmonary fibrosis. Int. J. Clin. Exper. Path. 4(3): 241-54. PMCID: PMC3071657
Kliment CR, Englert JM, Crum LP, Oury TD. (2011) A novel method for accurate collagen and biochemical assessment of pulmonary tissue utilizing one animal. Int. J. Clin. Exper. Path. 4(4): 349-55. PMID: 21577320 [PubMed - in process]
Ramsgaard L, Englert JM, Manni ML, Milutinovic PS, Gefter J, Tobolewski J, Tomai L, Coudriet GM, Piganelli J, Zamora R, Vodovotz Y, Enghild JJ, Oury TD. (2011) Lack of the receptor for advanced glycation end-products attenuates E. coli pneumonia in mice. PLoS ONE. 6(5): e20132. doi: 10.1371/journal.pone.0020132.
Manni ML, Epperly MW, Han W, Blackwell TS, Duncan SR, Piganelli JD, Oury TD. (2011) Leukocyte-derived extracellular superoxide dismutase does not contribute to airspace EC-SOD after interstitial pulmonary injury. Am J Physiol (Lung Cell Mol Physiol). 302: L160-6. PMID: 22003088 [PubMed - in process]
Manni ML, Czajka C, Oury TD, Gilbert T. (2011) Extracellular matrix powder protects against bleomycin induced pulmonary fibrosis. Tissue Engineering. 17: 2795-804. PMID: 21797754 [PubMed - in process] PMCID: PMC3204203 [Available on 2012/11/1]
Kawakami T, Puri N, Sodhi K, Bellner L, Takahashi T, Morita K, Oury TD, Abraham NG. (2012) Reciprocal Effects of Oxidative Stress on Heme Oxygenase Expression and Activity Contributes to Reno-Vascular Abnormalities in EC-SOD Knockout Mice. Int. J. of Hypertension. 2012: Article ID: 740203 (11 pages)
Milutinovic PS, Alcorn JF, Englert JM, Crum LT, Oury TD. (2012) The receptor for advanced glycation end-products is a central mediator of asthma pathogenesis. Am. J. Pathol. In Press.