Shih-Fan Kuan, MD, PhD
Associate Professor of Pathology

r. Kuan is a surgical pathologist with subspecialty focussed in gastrointestinal pathology.

Office Location:
UPMC Presbyterian Hospital
Room A610-2
200 Lothrop Street
Pittsburgh, PA 15213
Contact Information:
Office Telephone: 412-647-1248


  • MD - National Taiwan University, Taipei, 1977
  • PhD - University of California, San Francisco, 1988

Clinical Expertise

Dr. Kuan is a surgical pathologist with a subspecialty focused in gastrointestinal pathology.

Research Interests

Dr. Kuan is a gastrointestinal surgical pathologist. His research interests are centered around 3 main areas:
  • regulation and expression of mucin genes in normal, preneoplastic and neoplastic cells and tissue in GI tract
  • the molecular classification of colorectal and appendiceal cancers
  • the serrated neoplastic pathway in colorectal cancer including microsatellite instable colon cancer and its precursors (SSA, TSA, mixed polyp)


Anatomic Pathology


Gastrointestinal Pathology

Selected Publications

View Dr. Kuan's publications on PubMed

Hu H, Chang DT, Nikiforova MN, Kuan SF, Pai RK. Clinicopathologic features of synchronous colorectal carcinoma: a distinct subset arising from multiple sessile serrated adenomas & associated with high levels of microsatellite instability & favorable prognosis. Am J Surg Pathol 2013; 37:1660-70

Kuan SF, Navina S, Cressman KL, Pai RK. Immunohistochemical detection of BRAF V600E mutant protein using the VE1 antibody in colorectal carcinoma is highly concordant with molecular testing but requires vigorous antibody optimization. Human Pathol 2014; 45:464-72

Davison JM, Ellis ST, Foxwell TJ, Luketich JD, Gibson MK, Kuan SF, Nason KS. MUC2 expression is an adverse prognostic factor in superficial gastroesophageal adenocarcinomas. Human Pathol 2014; 45: 540-8

Pai RK, Hartman DJ, Gonzalo DH, Lai KK, Goldblum JR, Kuan SF, Nikiforova MN, Pai RK. Serrated lesions of the appendix frequently harbor KRAS mutations and not BRAF mutations indicating distinctly different serrated neoplastic pathway in the appendix. Human Pathol 2014; 45:227-35.

Boichuck S, Lee DJ, Mehalek KR, Kuan SF, Debiec-Rychter M, Duensing A. Unbiased compound screening identifies unexpected drug sensitivities and novel treatment options for gastrointestinal stromal tumors. Cancer Res2014; 74:1200-13.

Landau MS, Kuan SF, Chiosea S, Pai RK. BRAF-mutated microsatellite stable colorectal carcinoma: an aggressive adenocarcinoma with reduced CDX2 and increased cytokeratin 7 immunohistochemical expression. Human Pathol 2014; 45:1704-12

Chintamaneni P, Das R, Kuan SF, Kermanshahi TR, Hashash JG. Hematochezia associated with Sevalamer-induced mucosal injury. ACG Case Reports Journal 2014; 1:145-7