Alyssa M. Krasinskas, MD
Associate Professor of Pathology


Dr. Krasinskas is a member of the Division of Anatomic Pathology and director of the Gastrointestinal Pathology Center of Excellence and Gastrointestinal Pathology Fellowship Program.
Office Location:
Rm. A610
UPMC Presbyterian
200 Lothrop Street
Pittsburgh, PA 15213-2546 		Contact Information:
Office Telephone: 412-647-0282
Email: krasinskasam@upmc.edu

Education

  • BA - 1990, Clark University
  • MD - 1994, University of Rochester School of Medicine and Dentistry
  • AP/CP Pathology Residency - 2001, University of Pennsylvania
  • Pathology Fellowship - 2002, Surgical and Gastrointestinal Pathology, University of Pennsylvania

Clinical Expertise

Dr. Krasinskas is an Academic Surgical Pathologist with a subspecialty interest and focus in Gastrointestinal and Pancreatic pathology. She also consults on surgical pathology cases involving the luminal GI tract and pancreas.

Research Interests

My current primary research interests are in the field of pancreatic cancer and other neoplasms: the molecular pathogenesis of pancreatic cancer, assessing the effect of neoadjuvant therapy on pancreatic cancer, and classifying benign mucinous cysts of the pancreas. Other areas of research interest include the study of peritoneal mesotheliomas and microsatellite instability in colon cancer. I have over 90 peer-reviewed publications, additional review articles and book chapters, and I am a co-investigator on institutional grants.

Certifications

Diplomate of the American Board of Pathology in combined Anatomic Pathology and Clinical Pathology

Specialties

Surgical Pathologist with subspecialty interest and training in gastrointestinal / pancreatic pathology

Awards and Honors

  • Victor M. Emmel Award for Excellence in Histology, University of Rochester
  • George H. Whipple, MD Academy of Medicine Award for Contributing to the Progress of Medicine, University of Rochester
  • American Society of Transplantation Young Investigator Award
  • The H.T. Enterline Fellowship Award for Excellence in Diagnostic Skills, Commitment to Teaching and Scholarly Activity, University of Pennsylvania
  • Rodger C. Haggitt Gastrointestinal Pathology Society Award to Chad Rund for Best Presentation by a Resident/Fellow at the annual USCAP meeting (Mentor and Senior Author)

Selected Publications

View Dr. Krasinskas' recent publications on PubMed
View Dr. Krasinskas' previous publications on PubMed

  1. Krasinskas AM, Bartlett D, Cieply K, Dacic S. CDKN2A and MTAP Deletions in Peritoneal Mesotheliomas are Correlated with Loss of p16 Protein Expression and Survival. Mod Pathol. 2010; 23(4):531-8.
  2. Bell LN, Temm CJ, Saxena R, Vuppalanchi R, Schauer P, Rabinovitz M, Krasinskas A, Chalasani N, Mattar SG. Bariatric surgery-induced weight loss reduces hepatic lipid peroxidation levels and affects hepatic cytochrome P-450 protein content. Ann Surg. 2010;251(6):1041-8.
  3. Fasanella KE, Krasinskas A, Schoedel KE, Sasatomi E, Slivka A, Whitcomb DC, Sanders M, Nodit L, Raab S, McGrath KM, Ohori NP, Khalid A. DNA Mutational Differences in Cytological Specimens from Pancreatic Cancer and Cholangiocarcinoma. Pancreatology. 2010;10(4):429-433.
  4. Raval JS, Zeh HJ, Moser AJ, Lee KK, Sanders MK, Navina S, Kuan SF, Krasinskas AM. Pancreatic lymphoepithelial cysts express CEA and can contain mucous cells: potential pitfalls in the preoperative diagnosis. Mod Pathol. 2010;23(11):1467-76.
  5. Oruç N, Ozütemız O, Tekın F, Sezak M, Tunçyürek M, Krasinskas AM, Tombuloğlu M. Celiac disease associated with B-cell lymphoma. Turk J Gastroenterol. 2010;21(2):168-71.
  6. Ohike N, Kim GE, Tajiri T, Krasinskas A, Basturk O, Coban I, Bandyopadhyay S, Morohoshi T, Goodman M, Kooby DA, Sarmiento JM, Adsay NV. Intra-ampullary Papillary-Tubular Neoplasm (IAPN): Characterization of Tumoral Intraepithelial Neoplasia Occurring Within the Ampulla: A Clinicopathologic Analysis of 82 Cases. Am J Surg Pathol. 2010;34(12):1731-1748.
  7. Ohike N, Coban I, Kim GE, Basturk O, Tajiri T, Krasinskas A, Bandyopadhyay S, Morohoshi T, Shimada Y, Kooby DA, Staley CA, Goodman M, Volkan Adsay N. Tumor budding as a strong prognostic indicator in invasive ampullary adenocarcinomas. Am J Surg Pathol. 2010;34(10):1417-24.
  8. Bao PQ, Ramanathan RK, Krasinkas A, Bahary N, Lembersky BC, Bartlett DL, Hughes SJ, Lee KK, Moser AJ, Zeh HJ. Phase II Study of Gemcitabine and Erlotinib as Adjuvant Therapy for Patients with Resected Pancreatic Cancer. Ann Surg Oncol. 2011 Apr;18(4):1122-9.
  9. Monaco SE, Shuai Y, Bansal M, Krasinskas AM, Dacic S. The diagnostic utility of p16 FISH and GLUT-1 immunohistochemical analysis in mesothelial proliferations. Am J Clin Pathol. 2011;135(4):619-27.
  10. Radu O, Nikifirov M, Farkas L, Krasinskas AM. Challenging cases encountered in colorectal cancer screening for Lynch syndrome reveal novel findings: Nucleolar MSH6 staining and impact of prior chemoradiation therapy. Hum Pathol. 2011;42(9):1247-58.
  11. Woodard AH, Yu J, Dabbs DJ, Beriwal S, Florea AV, Elishaev E, Davison JM, Krasinskas AM, Bhargava R. NY-BR-1 and PAX8 Immunoreactivity in Breast, Gynecologic Tract, and Other CK7+ Carcinomas: Potential Use for Determining Site of Origin. Am J Clin Pathol. 2011;136(3):428-35.
  12. Gao FF, Krasinskas AM, Chivukula M. Is PAX2 a reliable marker in differentiating diffuse malignant mesotheliomas of peritoneum from serous carcinomas of müllerian origin? Applied Immunohistochemistry & Molecular Morphology. Am J Clin Pathol. 2011 Sep;136(3):428-35.
  13. Rollins-Raval M, Felgar R, Krasinskas A, Roth C. Increased IgG4-positive plasma cells may rarely be seen in lymph nodes of patients without IgG4-related sclerosing disease. International Journal of Surgical Pathology. 2011 Sep 12. [Epub ahead of print]
  14. Hastings S, Levinthal D, Krasinskas AM. Small non-descript ulcers with an uncommon etiology. Gastroenterology. 2012 Feb 24. [Epub ahead of print]
  15. Baumgartner JM, Krasinskas A, Daouadi M, Zureikat A, Marsh W, Lee K, Bartlett D, Moser AJ, Zeh HJ 3rd. Distal Pancreatectomy with En Bloc Celiac Axis Resection for Locally Advanced Pancreatic Adenocarcinoma Following Neoadjuvant Therapy. J Gastrointest Surg. 2012 Mar 8. [Epub ahead of print]
  16. Goodell PP, Krasinskas AM, Davison JM, Hartman DJ. Comparison of methods for proliferative index analysis for grading pancreatic well-differentiated neuroendocrine tumors. Am J Clin Pathol. 2012 Apr;137(4):576-82.
  17. Jindal N, Yadav D, Passero C, Krasinskas A, Craig F, Bastacky S, Liang KV. Membranous nephropathy: a rare renal manifestation of IgG4-related systemic disease. Clin Nephrol. 2012 Apr;77(4):321-8.