Julia Kofler, MD
Assistant Professor of Pathology

Dr. Kofler
Dr. Kofler is a member of the Division of Neuropathology.
Office Location:
S701.3 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
Contact Information:
Office Telephone: 412-624-6353
Fax: 412-624-5610
Email: koflerjk@upmc.edu

Education

  • MD - University of Vienna, 1997

Clinical Expertise

  • Surgical neuropathology
  • Autopsy neuropathology
  • Ophthalmic pathology
  • Neurodegenerative diseases
    • Neuropathology core director of the University of Pittsburgh Alzheimer's disease research center (ADRC)
    • Neuropathologist for the University of Pittsburgh ALS center
    • CJD autopsy cases, in collaboration with the National Prion Disease Pathology Surveillance Center

Research Expertise

Dr Kofler's research focuses on the role of microglial cells in aging and neurodegenerative diseases. She is particularly interested in investigating different pathways of microglial polarization including classical and alternative activation paradigms. In addition, her lab recently started to study the impact of polymorphisms in inflammation-associated genes on pathology patterns in Alzheimer's disease. Experiments are performed in primary microglial cell cultures derived from human postmortem brain tissue, primary human macrophages, macrophage cell lines, and tissue samples from the ADRC brain bank. The goal of her research is to arrive at a better understanding of distinct microglial functions and activation patterns in order to selectively modulate the innate immune response in the brain as a means to prevent pathological aging and/or modify the course of AD.

Selected Publications

View Dr. Kofler's publications on PubMed

  1. Bonneh-Barkay D, Bissel SJ, Kofler J, Starkey A, Wang G, Wiley CA. Astrocyte and macrophage regulation of YKL-40 expression and cellular response in neuroinflammation. Brain Pathol 2012;22:530-46 (PMCID: PMC3557465)
  2. Kofler J, Lopresti B, Janssen C, Trichel AM, Masliah E, Finn OJ, Salter RD, Murdoch GH, Mathis CA, Wiley CA. Preventive immunization of aged and juvenile non-human primates to beta-amyloid. J Neuroinflammation 2012;9:84 (PMCID: PMC3495408)
  3. Murray PS, Kirkwood CM, Gray MC, Ikonomovic MD, Paljug WR, Abrahamson EE, Henteleff RA, Hamilton RL, Kofler J, Klunk WE, Lopez OL, Penzes P, Sweet RA. ?-Amyloid 42/40 ratio and kalirin expression in Alzheimer disease with psychosis. Neurobiol Aging 2012;33:2807-16 (PMCID: PMC3381843)
  4. Spina S, Van Laar A, Murrell J, Hamilton R, Kofler J, Epperson F, Farlow M, Lopez O, Quinlan J, DeKosky S, Ghetti B. Phenotypic variability in three families with Valosin-Containing Protein mutation. Eur J Neurol 2013;20:251-8 (PMCID: PMC3734548)
  5. Koutourousiou M, Gardner P, Fernandez-Miranda JC, Kofler J?, Snyderman, Lunsford LD. Rare infundibular tumors: clinical presentation, imaging findings and the role of endoscopic endonasal surgery in their management. J Neurol Surg - Skull Base 2013;74:1-11.
  6. Venneti S, Madden ME, Coyne T, Phillips JJ, Gorovets D, Huse JT, Kofler J, Lu C, Tihan T, Sullivan LM, Santi M, Judkins AR, Perry A, Thompson CB. Histone 3 lysine 9 trimethylation (H3K9me3) is differentially associated with isocitrate dehydrogenase 1 (IDH1) R132H mutations in oligodendrogliomas and high-grade astrocytomas. J Neuropath Exp Neurol 2013;72:298-306 (PMCID: PMC3615673).
  7. Murray PS, Kirkwood CM, Gray MC, Fish KN, Ikonomovic MD, Hamilton RL, Kofler JK, Klunk WE, Lopez OL, Sweet RA. Hyperphosphorylated tau is elevated in Alzheimer disease with psychosis. J Alz Dis 2014;39:759-73.
  8. Gallagher MD, Suh E, Grossman M, Elman L, McCluskey L, Van Swieten JC, Al-Sarraj S, Neumann M, Gelpi E, Ghetti B, Rohrer JD, Halliday G, Van Broekchoven C, Seilhean D, Shaw PJ, Frosch MP, International Collaboration for Frontotemporal Lobar Degeneration (Kofler J listed as collaborator), Trojanowski JQ, Lee VM, Van Deerlin V, Chen-Plotkin AS: TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions. Acta Neuropathologica 2014;127:407-18.
  9. Koppel J, Acker C, Davies P, Jimenez H, Lopez O, Azose M, Greenwald B, Murray P, Kirkwood C, Kofler J, Sweet R. Psychotic Alzheimer's disease is associated with gender-specific tau phosphorylation abnormalities. Neurobiology of Aging 2014;35:2012-8.
  10. Vatsavayi AV, Kofler J, Demichele-Sweet MA, Lopez OL, Sweet RA. TAR DNA-binding protein 43 pathology in Alzheimer's disease with psychosis. Int Psychogeriatr 2014 Mar 4:1-8
  11. Beecham GW, Hamilton K, Naj AC, Martin ER, Huentelman M, Myers AJ, Corneveaux JJ, Hardy J, Vonsattel JP, Younkin SG, Bennett DA, De Jager PL, Larson EB, Crane PK, Kamboh MI, Kofler JK, Mash DC, Duque L, Gilbert JR, Gwirtsman H, Buxbaum JD, Kramer P, Dickson DW, Farrer LA, Frosch MP, Ghetti B, Haines JL, Hyman BT, Kukull WA, Mayeux RP, Pericak-Vance MA, Schneider JA, Trojanowski JQ, Reiman EM, the Alzheimer's Disease Genetics Consortium (ADGC), Schellenberg GD, Montine TJ. Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. PLOS Genetics 2014 (in press)
  12. Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, Hyman BT, Jellinger K, Jicha GA, Kovacs GG, Knopman DS, Kofler J, Kukull WA, Mackenzie IR, Masliah E, McKee A, Montine TJ, Murray ME, Neltner JH, Santa-Maria I, Seeley WW, Serrano-Pozo A, Shelanski ML, Stein T, Takao M, Thal DR, Toledo JB, Troncoso JC, Vonsattel JP, White CL 3rd, Wisniewski T, Woltjer RL, Yamada M, Nelson PT. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol 2014 (in press).