Zahida Khan, MD, PhD
Assistant Professor of Pediatrics and Pathology


Dr. Khan is an Assistant Professor in Pediatric Gastroenterology and Pathology. Her clinical appointment is at Children's Hospital of Pittsburgh (CHP). She is also a member faculty of the McGowan Institute for Regenerative Medicine. Dr. Khan has longstanding clinical and research interests in pediatric hepatology and liver transplant. She specializes in the medical care of children before and after liver transplant, and treats patients with acute and chronic liver diseases. Her research focuses on cellular approaches to liver regeneration and transplantation. Dr. Khan studies mechanisms of hepatocyte regeneration in alpha-1 antitrypsin deficiency, the most common inherited cause of pediatric liver disease and transplantation. Her work investigates critical cellular signals for liver regeneration, including (1) bile acid signaling, and (2) the liver stem cell marker LGR5 (Leucine-rich repeat-containing G-protein coupled receptor 5). Dr. Khan plans to extend these studies by developing cellular and molecular therapies for liver-based metabolic diseases.

Office Location:
Children's Hospital of Pittsburgh of UPMC
Division of Gastroenterology, Hepatology & Nutrition
4401 Penn Avenue, Faculty Pavilion 6th Floor
Pittsburgh, PA 15224-1334
Contact Information:
Office Phone: 412-692-5180
Lab Telephone: 412-383-8787
Email: zahida.khan@chp.edu

Education

  • BS - 1998, Simmons College
  • PhD - 2006, University of Pittsburgh School of Medicine
  • MD - 2008, University of Pittsburgh School of Medicine

Specialties

Residency: General Pediatrics, Cincinnati Children's Hospital Medical Center, 2011.
Fellowship: Pediatric Gastroenterology, Children's Hospital of Pittsburgh of UPMC, 2015
Fellowship: Advanced Pediatric Transplant Hepatology, Texas Children's Hospital, Baylor College of Medicine, 2017

Certifications

American Board of Pediatrics (General Pediatrics, Pediatric Gastroenterology)
BE for Pediatric Transplant Hepatology CAQ

Clinical Expertise

Pediatric gastroenterology, hepatology and liver transplantation
Pediatric metabolic liver diseases

Research Expertise

Liver stem cells, regeneration, and transplantation
Transdifferentiation
Bile acid signaling
Cell therapy for liver diseases

Awards and Honors:

  • Top Research Abstract Award, Baylor Pediatric Symposium, 2017
  • Innovation Development Grant, CHP Hillman Transplant Foundation, 2016
  • Pilot & Feasibility Grant, Alpha-1 Foundation, 2015-2016, 2016-2017
  • CHP Scholars K12 Career Development Award, 2015-2016
  • Studies in Pediatric Liver Transplantation (SPLIT) Annual Meeting Travel Award, 2014
  • Pennsylvania Society of Gastroenterology (PSG) Annual Scientific Meeting Travel Award and Second Prize, Best Poster Presentation, 2014
  • NASPGHAN Teaching and Tomorrow Program, 2009
  • Friends of ISMETT Medical Student Scholarship, 2008
  • Cellular Approaches to Tissue Engineering and Regeneration (CATER) Certificate, 2006

Selected Publications

View Dr. Khan's publications on PubMed

  1. Michalopoulos GK, Khan Z. Liver regeneration, growth factors, and amphiregulin. Gastroenterology 2005 Feb;128(2):503-506. PMID: 15685562.
  2. Khan Z, Michalopoulos GK, Stolz DB. Peroxisomal localization of hypoxia-inducible factors and HIF regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation. Am J Pathol. 2006 Oct;169(4):1251-1269. PMID: 17003483.
  3. Khan Z, Stolz DB, Crawford JM. "Ultrastructure of the hepatocyte" in Textbook of Hepatology: from Basic Science to Clinical Practice, Third ed. Blackwell. J.P. Benhamou, A. Blei, J-F Dufour, P. Ginès, S. Friedmann, J. Reichen, J. Rodes, C. Valla, F. Zoulim (Ed.), Oxford University Press 2007, New York, pp. 20-28.
  4. Khan Z, Sciveres M, Salis P, Minervini M, Maggiore G, Cintorino D, Riva S, Gridelli B, Emma F, Spada M. Combined split liver and kidney transplant in a 3-year-old child with primary hyperoxaluria type 1 and complete thrombosis of the inferior vena cava. Pediatr. Transplant. 2011 Jun;15(4):E64-70. PMID: 19793227.
  5. Khan Z, Tafaleng EN, Soltys KA, Fox IJ. "Congenital and acquired diseases of the liver" in Translational Gastroenterology: Organogenesis to Disease, First ed. D.L. Gumucio, L.C. Samuelson, J.R. Spence (Ed.), John Wiley & Sons 2014, West Sussex, UK, pp. 165-178.
  6. Michalopoulos GK, Khan Z. Liver stem cells: Experimental findings and implications for human liver disease. Gastroenterology 2015 October;149(4):876-882. PMID: 26278502.
  7. Khan Z, Orr A, Stolz DB, Michalopoulos GK, Ranganathan S. Immunohistochemical analysis of the stem cell marker LGR5 in pediatric liver disease. Pediatr. Dev. Pathol. 2017 Jan/Feb;20(1):16-27. PubMed PMID: 28276299.
  8. Khan Z, Soltys KA, Venkat VL, Ranganathan S. A challenging case of severe infantile cholestasis in A1AT deficiency. Pediatr. Dev. Pathol. 2017 Mar/Apr;20(2):176-181. PubMed PMID: 28326955.
  9. Khan Z, Yokota S, Ono Y, Bell AW, Oertel M, Stolz DB, Michalopoulos GK. Bile duct ligation induces ATZ globule clearance in a mouse model alpha-1 antitrypsin deficiency. Gene Exp. 2017 Feb;17(2)115-127. PubMed PMID: 27938510. [COVER IMAGE]
  10. Khan Z, Strom SC. "Hepatocyte transplantation in special populations: Clinical use in children" in Hepatocyte Transplantation: Methods and Protocols, Second ed. Methods Mol Biol. 2017;1506:3-16. PubMed PMID: 27830542.