Zahida Khan, MD, PhD
Assistant Professor of Pediatric Gastroenterology and Pathology


Dr. Khan is an instructor in Pediatric Gastroenterology and Pathology. Her clinical appointment is at Children's Hospital of Pittsburgh (CHP). She is also a member faculty of the McGowan Institute for Regenerative Medicine. Dr. Khan has longstanding clinical and research interests in pediatric hepatology and liver transplant. Her research focuses on cellular approaches to liver regeneration and transplantation. Dr. Khan studies mechanisms of hepatocyte regeneration in alpha-1 antitrypsin deficiency, the most common inherited cause of pediatric liver disease and transplantation. Her work investigates critical cellular signals for liver regeneration, including (1) bile acid signaling, and (2) the liver stem cell marker LGR5 (Leucine-rich repeat-containing G-protein coupled receptor 5). Dr. Khan plans to extend these studies by developing cellular and molecular therapies for liver-based metabolic diseases.

Office Location:
Children's Hospital of Pittsburgh of UPMC
Division of Gastroenterology, Hepatology & Nutrition
4401 Penn Avenue, Faculty Pavilion 6th Floor
Pittsburgh, PA 15224-1334
Contact Information:
Office Phone: 412-692-5180
Lab Telephone: 412-383-8787
Email: zahida.khan@chp.edu

Education

  • BS - 1998, Simmons College
  • PhD - 2006, University of Pittsburgh School of Medicine
  • MD - 2008, University of Pittsburgh School of Medicine

Specialties

Residency: General Pediatrics, Cincinnati Children's Hospital Medical Center, 2011.
Fellowship: Pediatric Gastroenterology, Children's Hospital of Pittsburgh of UPMC, 2015

Certifications

American Board of Pediatrics (General Pediatrics, Pediatric Gastroenterology)
Cellular Approaches to Tissue Engineering and Regeneration (CATER) Certificate, McGowan Institute for Regenerative Medicine, 2006.

Clinical Expertise

Pediatric gastroenterology and hepatology
Pediatric metabolic liver diseases

Research Expertise

Liver stem cells, regeneration, and transplantation
Transdifferentiation
Bile acid signaling
Cell therapy for liver diseases

Selected Publications

View Dr. Khan's publications on PubMed

  1. Michalopoulos GK, Khan Z. Liver regeneration, growth factors, and amphiregulin. Gastroenterology 2005 Feb;128(2):503-506. PMID: 15685562.
  2. Khan Z, Michalopoulos GK, Stolz DB. Peroxisomal localization of hypoxia-inducible factors and HIF regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation. Am J Pathol. 2006 Oct;169(4):1251-1269. PMID: 17003483.
  3. Khan Z, Stolz DB, Crawford JM. "Ultrastructure of the hepatocyte" in Textbook of Hepatology: from Basic Science to Clinical Practice, Third ed. Blackwell. J.P. Benhamou, A. Blei, J-F Dufour, P. Ginès, S. Friedmann, J. Reichen, J. Rodes, C. Valla, F. Zoulim (Ed.), Oxford University Press 2007, New York, pp. 20-28.
  4. Khan Z, Sciveres M, Salis P, Minervini M, Maggiore G, Cintorino D, Riva S, Gridelli B, Emma F, Spada M. Combined split liver and kidney transplant in a 3-year-old child with primary hyperoxaluria type 1 and complete thrombosis of the inferior vena cava. Pediatr. Transplant. 2011 Jun;15(4):E64-70. PMID: 19793227.
  5. Khan Z, Tafaleng EN, Soltys KA, Fox IJ. "Congenital and acquired diseases of the liver" in Translational Gastroenterology: Organogenesis to Disease, First ed. D.L. Gumucio, L.C. Samuelson, J.R. Spence (Ed.), John Wiley & Sons 2014, West Sussex, UK, pp. 165-178.
  6. Michalopoulos GK, Khan Z. Liver stem cells: Experimental findings and implications for human liver disease. Gastroenterology 2015 October;149(4):876-882. PMID: 26278502.
  7. Khan Z, Orr A, Stolz DB, Michalopoulos GK, Ranganathan S. Immunohistochemical analysis of the stem cell marker LGR5 in pediatric liver disease. Pediatr. Dev. Pathol. 2016 Mar 28. [Epub ahead of print] PMID: 27019151. In press.
  8. Khan Z, Soltys KA, Venkat VL, Ranganathan S. A challenging case of severe infantile cholestasis in A1AT deficiency. Pediatr. Dev. Pathol. 2016 Feb 8. [Epub ahead of print] PMID: 26855337. In press.
  9. Khan Z. Pathogenesis of alpha-1 antitrypsin deficiency in the liver: New approaches to old questions. J. Liver Res. Disord. Ther. 2016 May 6. In press.