Anna E Lokshin, PhD
Associate Professor
Email: lokshina@pitt.edu
Research Interest:
Dr. Lokshin is an Associate Professor of Medicine with joint appointments as Associate Professor of Pathology and Ob/Gyn Reproductive Sciences. Dr. Lokshin is also a Director of Luminex Core Facility of UPCI. Dr. Lokshin's research is focused on identification of cancer biomarkers for screening, diagnosis, prognosis, and disease monitoring of solid tumor cancers including ovarian, endometrial, breast, lung, pancreatic, HCC, and others. Dr. Lokshin is utilizing multiplexing approach that enables analysis of over hundred of candidate proteins in small blood sample. This approach allows for identification of proteins whose associations with particular cancers have not been previously reported, such as prolactin, eotaxin-1, RANTES, and others. Dr. Lokshins's laboratory investigates the roles and mechanisms of activity of these proteins in several cancers. Dr. Lokshin's laboratory also studies cancer stem cells, cancer stem cells biomarkers, and mechanisms of cancer stem cells drug resistance.
Recent Publication
Linkov F, Lisovich A, Yurkovetsky Z, Marrangoni A, Velikokhatnaya L, Bigbee WL, Siegfried J, Nolen B, Winans M, Lokshin A, and Ferris RL. Early Detection of Head and Neck Cancer: Development of a Novel Screening Tool Using Multiplexed Immunobead-Based Biomarker Profiling. Cancer Epidemiol Biomarkers Prevention. 2007;16(1):102-7
Yurkovetsky Z, Kirkwood JM, Edington HD, Lisovich A, Marrangoni AM, Velikokhatnaya L, Winans M, Gorelik E, and Lokshin A. Multiplex Analysis of Serum Cytokines in Melanoma Patients Treated with IFN-¦Á2b. Clinical Cancer Research. 2007 Apr 15;13(8):2422-8
Shurin M.R., Shurin G.V., Lokshin A., Yurkovetsky Z.R., Gutkin D.W., Chatta G.S., Zhong H., Han B., Ferris R.L. Intratumoral cytokines/chemokines.growth factors and tumor infiltrating dendritic cells: Friends or enemies? Cancer Metastasis Reviews, 2006,;25(3):333-56.
Yurkovetsky ZR, Linkov FY, E Malehorn D, Lokshin AE. Multiple biomarker panels for early detection of ovarian cancer. Future Oncol. 2007. 2(6):733-741.
Bast RC Jr, Brewer M, Zou C, Hernandez MA, Daley M, Ozols R, Lu K, Lu Z, Badgwell D, Mills GB, Skates S, Zhang Z, Chan D, Lokshin A, Yu Y. Prevention and early detection of ovarian cancer: mission impossible? Recent Results Cancer Res. 2007;174:91-100.
Parekh DJ, Ankerts DP, Thompson IM, Leah RJ, Troyer DA, Hernandez H, Baillargeon J, Lokshin A, Assessment of fifty-four biomarkers for biopsy-detectable prostate cancer. Cancer Epidemiol Biomarkers Prevention. 2007. 16(10):1966-72.
Zhong H, Han B, Tourkova IK, Lokshin A, Rosenbloom A, Shurin MR, Shurin GV. Low-Dose Paclitaxel Prior to Intratumoral Dendritic Cell Vaccine Modulates Intratumoral Cytokine Network and Lung Cancer Growth.
Pappas S, Federle MP, Lokshin AE, Zeh HJ 3rd. Early Detection and Staging of Adenocarcinoma of the Pancreas. Gastroenterol Clin North Am. 2007; 36(2):413-429.
Yurkovetsky Z, Ta'asan S, Rand A, Lomakin A, Linkov F, Marrangoni A, Velikokhatnaya L, Winans M, Gorelik E, Maxwell GL, Lu K, and Lokshin A. Development of multimarker panel for early detection of endometrial cancer. High diagnostic power of prolactin. Gynecol Oncol. 2007 Jul 18; [Epub ahead of print].
Linkov F, Yurkovetsky Z, Lokshin A. Biomarker approaches to the development of cancer screening tests: can cancer blood tests become a routine health check-up? Future Oncol. 2007 Jun;3(3):295-298.
Shurin GV, Yurkovetsky ZR, Chatta GS, Tourkova IL, Shurin MR, Lokshin AE. Dynamic alteration of soluble serum biomarkers in healthy aging. Cytokine. 2007 Aug;39(2):123-9.
Parekh DJ, Ankerts DP, Thompson IM, Leah RJ, Troyer DA, Hernandez H, Baillargeon J, Lokshin A. Assessment of fifty-four biomarkers for biopsy-detectable prostate cancer. Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):1966-72.
