Carol Feghali-Bostwick, Assistant Professor
Ph.D., Tulane University, New Orleans, LA
S-719 Biomedical Science Tower
200 Lothrop St.
Pittsburgh, PA 15261
Phone: (412) 383-8784
Fax: (412) 383-8753
Email: feghali2@pitt.edu
Home Page: http://paccm.upmc.edu/feghalica.htm
My laboratory focuses on identifying the role of insulin-like growth factor binding proteins in aberrant extracellular matrix production in Systemic Sclerosis (Scleroderma) and Idiopathic Pulmonary Fibrosis. We are currently examining the role of insulin-like growth factor binding proteins in the development of fibrosis in skin and lung fibroblasts derived from patients with Scleroderma and IPF. We are also conducting a study on twins with Scleroderma to delineate the role of environmental and genetic factors in the development of the disease.
Recent Publication
Pilewski, J.M., L. Liu, A. Henry, A.V. Knauer, and C.A. Feghali-Bostwick. Insulin-like growth factor binding proteins (IGFBP)-3 and ¨C5 are over-expressed in Idiopathic Pulmonary Fibrosis and contribute to extracellular matrix deposition. Am. J. Pathol. 166:399-407, 2005.
Xiong, M., C.A. Feghali-Bostwick, F.C. Arnett, and X. Zhou. A system biology approach to genetic studies of complex diseases. FEBS Lett. 579:5325-5332, 2005.
Zhou, X., F. Tan, M. Xiong, F.C. Arnett, and C.A. Feghali-Bostwick. Discordant scleroderma monozygotic twins show concordance for fibroblast gene expression profiles. Arthritis Rheum. 52:3305-3314, 2005.
Fischer, A., F.J. Pfalzgraf, C.A. Feghali-Bostwick, T.M. Wright, D. Curran-Everett, S.G. West, and K.K. Brown. Anti-Th/To-Positivity in a cohort of patients with Idiopathic Pulmonary Fibrosis. J. Rheumatol. 33:1600-1605, 2006.
Fischer, A., R.T. Meehan, G.P. Cosgrove, J. Portnoy, H.R. Collard, S.K. Frankel, C.A. Feghali-Bostwick, S.G. West, and K.K. Brown. Scleroderma sine scleroderma presenting as idiopathic interstitial lung disease. Chest. 2006. In press.
Yasuoka, H., D.M. Jukic, Z. Zhou, A.M.K. Choi, and C.A. Feghali-Bostwick. Insulin-like growth factor binding protein-5 induces skin fibrosis: a novel murine model for dermal fibrosis. Arthritis Rheum. 54:3001-3010, 2006.
Ning, W., Y. Dong, J. Sun, C. Li, M.A. Matthay, C.A. Feghali-Bostwick, and A.M. Choi. Cigarette smoke stimulates Matrix Metalloproteinase-2 Activity via EGR-1 in human lung fibroblasts. Am. J. Respir. Cell. Mol. Biol. 2006 Nov (Epub ahead of print).
Yasuoka, H., Z. Zhou, J.M. Pilewski, T.D. Oury, A.M.K. Choi, and C.A. Feghali-Bostwick. Insulin-like growth factor binding protein (IGFBP)-5 induces pulmonary fibrosis and triggers mononuclear cellular infiltration. Am. J. Pathol. 169:1633-1642, 2006.
Wang, XM, Zhang, Y, Kim, HP, Zhou, Z, Feghali-Bostwick, CA, Liu, F, Ifedigbo, E, Xu, X, Oury, TD, Kaminski, N, and Choi, AMK. Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. J. Exp. Med. 203:2895-2906, 2006.
Myerburg, M., J. Latoche, E. McKenna, L. Stabile, J. Siegfried, C. Feghali-Bostwick, and J. Pilewski. HGF and other fibroblast secretions modulate the phenotype of human bronchial epithelial cells. A. J. Physiol: Lung Cell. Mol. Physiol., 2007, in press.
