Marie C. DeFrances, Assistant Professor
PhD, University of Pittsburgh, 1995
MD, University of Pittsburgh, 1997
Email: defrancesmc@upmc.edu
HomePage:
Home Page:
Research Interests:
The main focus of Dr. DeFrances' research is PI3K signaling mechanisms in hepatocytes. She explores regulation of this signaling pathway at the molecular level using in vivo and in vitro models including overexpressing and null mouse models. Emphasis is also placed on unraveling the role of PI3K signaling in normal and neoplastic human and rodent liver. Dr. DeFrances' laboratory also explores tyrosine kinase pathways in liver growth, regeneration and neoplasia.
Recent Publication
Zhu, Z, , Z, Hu, X, Johnson, CJ, Stoops, J, Eaker, AE, Bell, A, Stoffer, D, Zarnegar, R., and DeFrances, M.C. (2007) "PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein" Biochem. and Biophys. Res. Commun. 358: 66-72
Wang, X. DeFrances, M.C., Dai, Y. Bell, A., Michalopoulos G.K. and R. Zarnegar (2002). A novel mechanism of cell survival: sequestration of the death receptor Fas by direct physical association with the tyrosine kinase receptor Met. Molecular Cell 9:411-422.
