Tim D. Oury, Associate Professor
MD, Duke University, 1994
PhD, Duke Univeersity, 1993
Email: tdoury@pitt.edu
Dr. Oury is a member of the Division of Molecular Diagnostics. More information about this division is available here. To see members of Dr. Oury's lab click here.
Dr. Oury is co-director of a program designed to transition physician scientist trainees into academic faculty professorships. For more information, please see the Pathologist Investigator Residency Training Program website at http://www.pathology.pitt.edu/PIRT. This combined Residency-Post-doctoral Research Fellowship or combined Residency-PhD program is designed to develop Academic Pathologists to become independent Principal Investigators and to play a leading role in combined research and diagnostic careers.
Dr. Oury's research interest in centered on the study of the antioxidant enzyme extracellular superoxide dismutase (EC-SOD). The lab is currently investigating the importance of extracellular oxidative stress in modulating pulmonary inflammation and fibrosis. Several other studies are centered on the importance of this enzyme in cardiac, renal and CNS diseases. The laboratory utilizes numerous transgenic and knockout animals as well as numerous animal models of disease. The laboratory also utilizes several biochemical and pathologic parameters to assess mechanisms involved in the pathogenesis of disease. Several in vitro systems are also utilized in the laboratory to study oxidative mechanisms involved in modification of extracellular proteins and glycosaminoglycans that contribute to inflammation and fibrosis.
To see members of Dr. Oury's lab click here.
To see Dr. Oury's web page listed at Pathology website click here
Recent Publication
Fattman CL, Tan RJ, Tobolewski JM, Oury TD. (2006) Increased sensitivity to asbestos-induced lung injury in mice lacking extracellular superoxide dismutase. Free Rad Biol Med.
Tan RJ, Fattman CL, Niehouse LM, Tobolewski JM, Hanford LE, Monzon FA, Li Q, Parks WC, Oury TD. (2006) Matrix Metalloproteinases Promote Inflammation and Fibrosis in Asbestos-induced Lung Injury in Mice. Am. J. Resp. Cell Molec. Biol. 35: 289-97.
Gao F, Kinnula VL, Myllärniemi M, Oury TD. (2008) Extracellular superoxide dismutase in pulmonary fibrosis. Antioxid Redox Signa. 10: 343-54.
Kliment, CR, Tobolewski, JM, Manni, ML, Tan, RJ, Enghild, JJ, Oury, TD. (2008) Extracellular superoxide dismutase protects against matrix degradation of heparan sulfate in the lung. Antioxid Redox Signa. 10: 261-68.
Englert JD, Hanford LE, Kaminski N, Tan RJ, Fattman CL, Tobolewski JM, Richards TJ, Loutaev I, Nawroth PP, Kasper M, Bierhaus A, Oury TD. (2008) A role for the receptor for advanced glycation end products in idiopathic pulmonary fibrosis. Am. J. Pathol. 172: 583-91.
Gao F. Koenitzer JR, Tobolewski JM, Jiang D, Liang J, Noble PW, Oury TD. (2008) Extracellular superoxide dismutase inhibits inflammation by preventing oxidative fragmentation of hyaluronan. J. Biol. Chem. 283: 6058-66.
Kliment CR, Engert JM, Gochuico B, Yu G, Kaminski N, Rosas I, Oury TD. (2009) Oxidative Stress Alters Syndecan-1 Distribution in the Lung During Pulmonary Fibrosis. J. Biol. Chem. In Press.
