Pathology Graduate Training Program
Cellular and Molecular Pathology (CMP) -
Current Graduate Students

Name: Edgar N. Tafaleng
Email: ent8@pitt.edu
Lab Phone: 412-692-9007
Mentor Name: Dr. Ira J. Fox

Undergraduate Education:
Undergraduate Degree: BS Molecular Biology and Biotechnology
Undergraduate Institution: University of the Philippines - Diliman

Research Project Information

Understanding the pathogenesis of alpha-1-antitrypsin deficiency mediated liver disease using patient-derived iPSc generated hepatocyte-like cells

Publications

Soto-Gutierrez A, Tafaleng E, Kelly V, Roy-Chowdhury J, Fox IJ. 2011. Modeling and therapy of human liver diseases using induced pluripotent stem cells: how far have we come? Hepatology 53(2):708-11.

Yagi H, Tafaleng E, Nagaya M, Hansel MC, Strom SC, Fox IJ, Soto-Gutierrez A. 2009. Embryonic and Induced Pluripotent Stem Cells as a Model for Liver Disease. Crit Rev Biomed Eng. Crit Rev Biomed Eng 37(4-5):377-98.

Abstracts:

In vitro differentiation of human embryonic stem cells to definitive endoderm is enhanced by bFGF and BMP4. Poster Presentation. University of Pittsburgh School of Medicine, Department of Pathology 10th Annual Retreat, Pittsburgh. May 2010.

Differentiation of human embryonic stem cells to definitive endoderm in vitro is enhanced by bFGF and BMP4. Poster Presentation. University of Pittsburgh School of Medicine, BGSA Symposium, Pittsburgh. September 2010.

Generation of induced pluripotent stem cells from alpha-1-antitrypsin deficient patients. Poster Presentation. University of Pittsburgh School of Medicine, Department of Pathology 11th Annual Retreat, Pittsburgh. May 2011.

Induced pluripotent stem cell lines from patients with alpha-1-antitrypsin deficiency-associated liver disease. Poster Presentation. University of Pittsburgh School of Medicine, BGSA Symposium, Pittsburgh. September 2011.

Induced pluripotent stem cell-derived hepatocytes from alpha-1-antitrypsin deficient patients model alpha-1-antitrypsin deficiency-associated liver disease. Poster Presentation. University of Pittsburgh School of Medicine, Department of Pathology 12th Annual Retreat, Pittsburgh. May 2012.

Induced pluripotent stem cell-derived hepatocytes from alpha-1-antitrypsin deficient patients model alpha-1-antitrypsin deficiency-associated liver disease. Oral Presentation. University of Pittsburgh School of Medicine, BGSA Symposium, Pittsburgh. October 2012.

Induced pluripotent stem cell-derived hepatocytes from alpha-1-antitrypsin deficient patients model alpha-1-antitrypsin deficiency. Poster Presentation. 63rd AASLD Liver Meeting, Boston. November 2012.

Modeling alpha-1-antitrypsin deficiency using patient-derived iPSc generated hepatocytes. Poster Presentation. University of Pittsburgh School of Medicine, Department of Pathology 13th Annual Retreat, Pittsburgh. May 2013

Modeling alpha-1-antitrypsin deficiency using patient-derived iPSc generated hepatocytes. Poster Presentation. 11th ISSCR Stem Cell Meeting, Boston. June 2013.

Modeling alpha-1-antitrypsin deficiency using patient-derived iPSc generated hepatocytes. Poster Presentation. 3rd Annual Rangos Research Symposium, Pittsburgh. June 2013.

Presentations:

Induced pluripotent stem cell-derived hepatocytes from alpha-1-antitrypsin deficient patients model alpha-1-antitrypsin deficiency. Oral Presentation. 2nd Annual Rangos Research Symposium, Pittsburgh. June 2012.

Induced pluripotent stem cell-derived hepatocytes from alpha-1-antitrypsin deficient patients model alpha-1-antitrypsin deficiency-associated liver disease. Oral Presentation. University of Pittsburgh School of Medicine, BGSA Symposium. October 2012.

Induced pluripotent stem cell-derived hepatocytes from alpha-1-antitrypsin deficient patients model alpha-1-antitrypsin deficiency. Oral Presentation. 63rd AASLD Liver Meeting. November 2012.

Modeling ?-1-antitrypsin deficiency using patient-derived iPSc generated hepatocytes. Oral Presentation. University of Pittsburgh School of Medicine, Department of Pathology 13th Annual Retreat. May 2013.