Pathology Graduate Training Program
Cellular and Molecular Pathology (CMP) -
Current Graduate Students

Name: Kathryn M. Sobek
Email: kmg55@pitt.edu
Lab Phone: 412-623-3929
Mentor Name: Dr. Denise O'Keefe

Undergraduate Education:
Undergraduate Degree: B.S. Microbiology and Molecular Genetics
Undergraduate Institution: Michigan State University

Research Project Information

I am studying the effect of a SNP, C421A in the protein ABCG2 in prostate cancer. I am also looking at the role folic acid plays in the regulation of ABCG2 expression.

Publications

Bacich, DJ, Sobek, KM, Cummings, JL, Atwood, AA, O'Keefe, DS. False negative results from using common PCR reagents. BMC Research Notes. 2011, 4:457

Madigan, AA, Sobek, KM, Cummings, JL, Green, WR, Bacich, DJ, O'Keefe, DS. Activation of innate anti-viral immune response genes in symptomatic benign prostatic hyperplasia. Genes and Immunity. 2012.

Abstracts:

Sobek, KM, Cummings, JL, Bacich, DJ, O'Keefe, DS. Implications of the ABCG2 Q141K variant in prostate cancer. University of Pittsburgh Cancer Institute Retreat, Pittsburgh, PA, June 2013. (poster)

Sobek, KM, Cummings, JL, Bacich, DJ, O'Keefe, DS. Implications of the ABCG2 Q141K variant in prostate cancer. University of Pittsburgh Pathology Retreat, Pittsburgh, PA, May 2013. (poster)

Sobek, KM, Cummings, JL, Bacich, DJ, O'Keefe, DS. ABCG2 Q141K variant effects prostate cancer patient progression-free survival, and folic acid and docetaxel efflux. Biomedical Graduate Student Association Symposium, Pittsburgh, PA. October 2012. (poster)

Sobek, KM, Cummings, JL, O'Keefe, DS. Effect of folic acid and docetaxel on the multidrug and folate transporter ABCG2 in prostate cancer. University of Pittsburgh Pathology Retreat, Pittsburgh, PA, May 2012. (poster)

Sobek, KM, Cummings, JL, O'Keefe, DS. Effect of folic acid and docetaxel on the multidrug and folate transporter ABCG2 in prostate cancer. American Association for Cancer Research Annual Meeting. Chicago, IL, April 2012. (poster)

Sobek, KM, O'Keefe, DS. Potential role of the novel nucleotide, 5-hydroxymethylcytosine, in epigenetic regulation of the multidrug transporter ABCG2. Society of Basic Urologic Research. November 2011. (poster)

Sobek, KM, O'Keefe, DS. Potential role of the novel nucleotide, 5-hydroxymethylcytosine, in epigenetic regulation of the multidrug transporter ABCG2. Biomedical Graduate Student Association Symposium. October 2011. (poster)

Sobek, KM, Tomaszewski, JJ, Cummings, JL, O'Keefe, DS. Effect of folic acid on epigenetic regulation of the multidrug and folate transporter ABCG2 in prostate cancer. UPCI Scientific Retreat, Pittsburgh PA, June 2011. (poster)

Sobek, KM, Tomaszewski, JJ, Cummings, JL, O'Keefe, DS. Effect of folic acid on epigenetic regulation of the multidrug and folate transporter ABCG2 in prostate cancer. University of Pittsburgh Pathology Retreat, Pittsburgh PA, June 2011. (poster)

Sobek, KM, Tomaszewski, JJ, Cummings, JL, O'Keefe, DS. Effect of folic acid on epigenetic regulation of the multidrug and folate transporter ABCG2 in prostate cancer. American Institute of Cancer Research Annual Conference. October 2010. (poster)

Sobek, KM, Tomaszewski, JJ, Cummings, JL, O'Keefe, DS. Effect of folic acid on epigenetic regulation of the multidrug and folate transporter ABCG2 in prostate cancer. Biomedical Graduate Student Association Symposium. October 2010. (poster)

Sobek, KM, Cummings JL, O'Keefe, DS. The effect of folate on ABCG2 expression and regulation in prostate cancer. University of Pittsburgh Cancer Institute Annual Retreat. June 2010. (poster)

Sobek, KM, Cummings JL, O'Keefe, DS. The effect of folate on ABCG2 expression and regulation in prostate cancer. Pathology Retreat. June 2010. (poster)

Sobek, KM, Cummings, JL, O'Keefe, DS. The effect of folate deprivation on ABCG2 expression and regulation in prostate cancer. Biomedical Graduate Student Association Symposium. October 2009. (poster)

Sobek, KM, Cummings, JL, O'Keefe, DS. Regulation of ABCG2 promoter methylation by folic acid in prostate cancer cells. UPCI Scientific Retreat. June 2009. (poster) Gonyea, KM, O'Keefe, DS. Identification of a novel retrovirus and global genome hypomethylation in benign prostatic hyperplasia. Society of Basic Urologic Research. November 2008. (poster-travel award winner)

Gonyea, KM, O'Keefe, DS. Identification of a novel retrovirus and global genome hypomethylation in benign prostatic hyperplasia. Biomedical Graduate Student Association Symposium. October 2008. (poster)

Presentations:

Implications of the ABCG2 Q141K variant in prostate cancer. University of Pittsburgh Prostate and Urologic Cancer Program Seminar Series. June 2013.

Effect of folic acid and docetaxel on the folate and multidrug transporter ABCG2 in prostate cancer. University of Pittsburgh Prostate and Urologic Cancer Program Seminar Series. May 2012.

Effect of folic acid on the multidrug and folate transporter ABCG2 in prostate cancer. University of Pittsburgh Prostate and Urologic Cancer Program Seminar Series. November 2010.

The Effect of Folate Deprivation on ABCG2 Expression and Regulation in Prostate Cancer. University of Pittsburgh Prostate and Urologic Cancer Program Seminar Series. September 2009.