Pathology Graduate Training Program
Cellular and Molecular Pathology (CMP) -
Current Graduate Students

Name: Brian Sicari
Email: Bms6@pitt.edu
Lab Phone: 412-648-2868
Mentor Name:Stephen Badylak, MD, Ph.D

Undergraduate Education:
Undergraduate Degree: B.S.
Undergraduate Institution: University of Pittsburgh

Research Project Information

Examining novel implantable biologic scaffold material technologies for clinical translation;

Implementing the use of biologic scaffolds composed of extracellular matrix in several preclinical and clinical scenarios;

Characterizing the cellular host innate immune response to implanted materials

Publications

Goh SK, Bertera S, Olsen P, Candiello JE, Halfter W, Uechi G, Balasubramani M, Johnson SA, Sicari BM, Kollar E, Badylak SF, Banerjee I. (2013). "Perfusion-decellularized pancreas as a natural 3D scaffold for pancreatic tissue and whole organ engineering." Biomaterials 34(28): 6760-72.

Sicari BM, Dearth CL, Badylak SF. (2013). Tissue engineering and regenerative medicine approaches to enhance the functional response of skeletal muscle injury. The Anatomic Review In Press.

Sicari BM, Agrawal V, Siu BF, Dearth CL, Turner NJ, Badylak SF. (2012). A murine model of volumetric muscle loss and a regenerative medicine approach for tissue replacement. Tissue Eng Part A 18(19-20): 1941-1948.

Sicari BM, Johnson SA, Siu BF, Crapo P, Daly KA, Jiang H, Medberry C, Tottey S, Turner N, Badylak SF. (2012) The Effect of Source Animal Age upon the In-Vivo Remodeling Characteristics of an Extracellular Matrix Scaffold. Biomaterials 33(22): 5524-5533.

Sicari BM, Troxell R, Salim F, Tanwir M, Takane KK, Fiaschi-Taesch N. (2012) c-myc and skp2 Coordinate p27 Degradation, Vascular Smooth Muscle Proliferation, and Neointima Formation Induced by the Parathyroid Hormone-Related Protein. Endocrinology. 2012 Feb;153(2):861-72.

Daly K, Liu S, Agrawal V, Brown B, Huber A, Johnson SA, Reing JE, Sicari BM, Wolf MT, Zhang X, Badylak SF. (2011) The Host Response to Endotoxin Contaminated Dermal Matrix. Tissue Eng Part A 18(11-12): 1293-1303.

Abstracts:

Sicari BM, Brown BN, Kukla KA, Zhang L, Turner NJ, Badylak S. Local macrophage polarization and tissue remodeling following bilateral implantation of ECM scaffold materials in the abdominal wall. TERMIS World Congress 2012 "Tissue Engineering and Regenerative Medicine" Vienna, Austria, Oral Presentation, September 5-8, 2012

Sicari BM, Siu B, Carey L, Turner N, Agrawal V, Badylak S. Macrophage and Progenitor Cell Participation in a Regenerative Medicine Approach to Volumetric Muscle Loss. TERMIS World Congress 2012 "Tissue Engineering and Regenerative Medicine" Vienna, Austria, September 5-8, 2012.

Sicari BM, Siu B, Agrawal V, Turner N, Badylak S. Preclinical and Clinical Evidence of Progenitor Cell Participation in the Remodeling of ECM Scaffolds Extracellular Matrix as a Scaffold for Tissue Replacement Following Volumetric Muscle Loss: Remodeling Characteristics from Animal Models and Human Patients. Regenerative Medicine Annual Conference and Exposition, Hilton Head, SC, March 14-17, 2012.

Sicari BM, Johnson SA, Siu BF, Crapo P, Daly KA, Jiang H, Medberry C, Tottey S, Turner N, Badylak SF. The Effect of Source Animal Age upon the In-Vivo Remodeling Characteristics of an Extracellular Matrix Scaffold. McGowan Retreat, Farmington PA, 2012.

Sicari BM, Agrawal V, Siu B, Turner N, Badylak S. Extracellular Matrix as a Scaffold for Tissue Replacement Following Volumetric Muscle Loss: Remodeling Characteristics from Animal Models and Human Patients. Tissue Engineering and Regenerative Medicine International Society (TERMIS), North America Annual Conference and Exposition, December 11-14. Oral Presentation, 2011.

Sicari BM, Agrawal V, Turner N, Badylak SF. Constructive remodeling by extracellular matrix scaffolds within the skeletal muscle microenvironment. Regenerative Medicine Annual Conference and Exposition, Hilton Head, SC, March 11-14, 2011

Sicari BM, Brown BN, Daly KA, Tottey S, Johnson SA, Badylak SF. Tissue remodeling characteristics of three different extracellular matrix configurations. McGowan Retreat, Farmington PA, 2010

Presentations:

Sicari BM, Brown BN, Kukla KA, Zhang L, Turner NJ, Badylak S. Local macrophage polarization and tissue remodeling following bilateral implantation of ECM scaffold materials in the abdominal wall. TERMIS World Congress 2012 "Tissue Engineering and Regenerative Medicine" Vienna, Austria, Oral Presentation, September 5-8, 2012

Sicari BM, Agrawal V, Siu B, Turner N, Badylak S. Extracellular Matrix as a Scaffold for Tissue Replacement Following Volumetric Muscle Loss: Remodeling Characteristics from Animal Models and Human Patients. Tissue Engineering and Regenerative Medicine International Society (TERMIS), North America Annual Conference and Exposition, December 11-14. Oral Presentation, 2011.