Pathology Graduate Training Program
Cellular and Molecular Pathology (CMP) -
Alumni

Name: Michelle Manni
Email: mlm45@pitt.edu
Lab Phone: 412-624-8888
Mentor Name: Tim D. Oury, MD PhD

Education:
Undergraduate Degree: BS
Undergraduate Institution: Allegheny College

Honors/Awards:

2001-03, 2004-05 Distinguished Alden Scholar, Allegheny College, Meadville, Pa
2003-04 Alden Scholar, Allegheny College, Meadville, Pa
2004 Beta Beta Beta National Biological Honor Society, Allegheny College, Meadville, Pa
2004 Phi Lambda Upsilon National Chemical Honor Society, Allegheny College, Meadville, Pa
2005 Phi Beta Kappa National Honor Society, Allegheny College,Meadville, Pa
2007 Young Investigator Award, 14th Annual Meeting for the Society for Free Radical Biology and Medicine, Washington D.C.

Publications:

Tan RJ. Lee JS. Manni ML. Fattman CL. Tobolewski JM. Zheng M. Kolls JK. Martin TR. Oury TD. 2006. Inflammatory cells as a source of airspace extracellular superoxide dismutase after pulmonary injury. American Journal of Respiratory Cell & Molecular Biology. 34:226-32.

Manni ML, Oury TD. 2007. Commentary on "Copper chaperone for Cu,Zn- SOD supplement potentiates the Cu,Zn-SOD function of neuroprotective effects against ischemic neuronal damage in the gerbil hippocampus". Free Radical Biology & Medicine. 43(6):899-900.

Blose JM, Manni ML, Klapec KA, Stranger-Jones Y, Zyra AC, Sim V, Griffith CA, Long JD, Serra MJ. 2007. Non-nearest-neighbor dependence of the stability for RNA bulge loops based on the complete set of group I single-nucleotide bulge loops. Biochemistry. 46:15123-35.

Kliment CR, Tobolewski JM, Manni ML, Tan RJ, Enghild J, Oury TD. 2008. Extracellular superoxide dismutase protects against matrix degradation of heparan sulfate in the lung. Antioxidant & Redox Signaling. 10:261-8.

Abstracts

Manni ML. Tobolewski JM. Oury TD. 2006. EC-SOD Prevents Oxidative Fragmentation of Type IV Collagen and Neutrophil Chemotaxis. 14th International Colloquium on Lung Fibrosis (ICLF), Eltville-Erbach, Germany, September 7-10, 2006.

Manni ML. Tobolewski JM. Oury TD. 2007. EC-SOD Prevents Oxidative Fragmentation of Type IV Collagen: A Potential Mechanism of its Anti-inflammatory Effects. Keystone Symposium: Molecular Mechanisms of Fibrosis, Tahoe City, CA, March 11-15, 2007.

Manni ML, Kliment CR, Duncan SR, Epperly MW, Piganelli JD, Oury TD. 2007. The Role of Leukocyte-derived EC-SOD in Pulmonary Inflammation. 14th Annual Meeting of the Society for Free Radical Biology and Medicine, Washington D.C., November 14-18, 2007. Oral Presentation

Manni ML, Tobolewski JM, Kliment CR, Duncan SR, Epperly MW, Piganelli JD, Oury TD. 2008. The Role of Leukocyte-derived EC-SOD in Pulmonary Inflammation. ATS 2008 - International American Thoracic Society Conference, Toronto, Canada, May 17-20, 2008. Poster Presentation

Research Support

Source/Project # or type (P.I.) American Heart Association Predoctoral Fellowship
Award #0715279U (Manni)
Project Period: 07/01/2007 - 06/30/2009
Annual Award (Role, % Effort): $21,000 (PI, 100%)

This grant investigates the role of leukocyte-derived EC-SOD in attenuating asbestos-induced interstitial lung injury.