Pathology Graduate Training Program
Cellular and Molecular Pathology (CMP) -
Current Graduate Students

Name: Lindsey M Kelly
Email: LMK66@pitt.edu
Lab Phone: 412-578-9208
Mentor Name: Yuri Nikiforov, MD, PhD

Undergraduate Education:
Undergraduate Degree: B.S., Biological Sciences
Undergraduate Institution: Duquesne University

Research Project Information

Novel mutations in thyroid cancer

Publications:

  1. Horbinski C, Kofler J, Kelly LM, Murdoch GH, Nikiforova MN. Diagnostic use of IDH1/2 mutation analysis in routine clinical testing of formalin-fixed, paraffin-embedded glioma tissues. J Neuropathol Exp Neurol 2009 Dec;68(12):1319-25.
  2. Horbinski C*, Kelly LM*, Nikiforov Y, Durso M B, Nikiforova MN. Detection of IDH1 and IDH2 Mutations by Fluorescence Melting Curve Analysis as a Diagnostic Tool for Brain Biopsies. J Mol Diagn. 2010 Jul;12(4):487-92. *Authors contributed equally to this work.
  3. Seethala RR, Dacic S, Cieply K, Kelly LM, Nikiforova MN. A reappraisal of the MECT1/MAML2 translocation in salivary mucoepidermoid carcinomas. Am J Surg Pathol. 2010 Aug;34(8):1106-21.
  4. Dacic S, Kelly LM, Nikiforova MN. miRNA expression profiling of lung adenocarcinomas: Correlation with mutational status. Mod Pathol. 2010 Dec;23(12):1577-82.
  5. Nikiforova MN, Gandi M, Kelly LM, Nikiforov YE. MicroRNA Dysregulation in Human Thyroid Cells Following Exposure to Ionizing Radiation. Thyroid. 2011 Mar;21(3):261-6.
  6. Yip L, Kelly LM, Shuai Y, Armstrong MJ, Nikiforov YE, Carty SE, Nikiforova MN. MicroRNA signature distinguishes the degree of aggressiveness of papillary thyroid carcinoma. Ann Surg Oncol. 2011 Jul;18(7):2035-41.
  7. Aggarwal N, Swerdlow SH, Kelly LM, Ogilvie JB, Nikiforova MN, Sathanoori M, Nikiforov YE. Thyroid carcinoma-associated genetic mutations also occur in thyroid lymphomas. Mod Pathol. 2012 May 11. doi: 10.1038/modpathol.2012.73.
  8. Gandhi M, Evdokimova VN, T Cuenco K, Nikiforova MN, Kelly LM, Stringer JR, Bakkenist CJ, Nikiforov YE. Homologous chromosomes make contact at the sites of double-strand breaks in genes in somatic G0/G1-phase human cells. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9454-9.

Abstracts:

  1. Kelly LM, Dipaola JE, Ohori NP, Nikiforov YE, Nikiforova MN. Detection of MicroRNA Expression in Thyroid Fine Needle Aspiration (FNA) Samples and Its Potential Diagnostic Utility 2007 Association for Molecular Pathology Annual Meeting, Journal of Molecular Diagnostics 2007:9 (5) 690.
  2. Nikiforova MN, Kelly LM, Dipaola JE, Nikiforov YE. microRNA markers of tumor aggressiveness in thyroid papillary carcinomas. 2008 79th Annual Meeting of American Thyroid Association, Thyroid 2008 18(1) S-10, #4
  3. Seethala RR, Kelly LM, Dipaola JE, Mantha G, Nikiforova MN. A novel assay for detection of MECT1/MAML2 translocation in mucoepidermoid carcinomas of the salivary glands. 2008 Association for Molecular Pathology Annual Meeting, J Mol Diagn 2008:10 (6) 610.
  4. Nikiforova MN, Kelly LM, Dipaola JD, Nikiforov YE miRNA markers of tumor aggressiveness in thyroid carcinomas. 2008 Association for Molecular Pathology Annual Meeting, J Mol Diagn 2008:10 (6) 602
  5. Seethala RR, Kelly LM, Nikiforov YE, Nikiforova MN. MicroRNA expression profiling of salivary duct carcinoma and pleomorphic adenomas of the parotid gland. USCAP, 98th Annual Meeting, 2009. Modern Pathology 2009, 22 (1), 251A, #1142
  6. Nikiforova MN, Dipaola JE, Kelly LM, Nikiforov YE. miRNA markers of aggressive behavior of papillary thyroid carcinoma. USCAP, 98th Annual Meeting, 2009. Modern Pathology 2009, 22 (1), 118A, #526
  7. Nikiforova MN, Kelly LM, Dipaola JD, Nikiforov YE. Novel miRNA-based method for preoperative diagnosis of thyroid FNA samples. 2009 World Congress on Thyroid Cancer, Congress Program 2009, 83, #O102.
  8. Kelly LM, Mantha G, Nikiforova MN. Optimization of miRNA Testing in Fine Needle Aspiration Samples and Formalin-Fixed Paraffin-Embedded Tissues, 15th Annual Meeting of Association for Molecular Pathology, Journal of Molecular Diagnostics, 2009 11(6), 656, #ST28
  9. Nikiforova MN, Kelly LM, DiPaola JE, Nikiforov YE. Clinical Validation of the Novel miRNA-based Assay for Preoperative Diagnosis of Thyroid FNA Samples, 15th Annual Meeting of Association for Molecular Pathology, Journal of Molecular Diagnostics, 2009 11(6), 656, #ST29
  10. Mantha GS, Harter A, Kelly LM, Nikiforova M. Diagnostic Challenges of Tissue Identity Testing in Anatomic Pathology, 15th Annual Meeting of Association for Molecular Pathology, Journal of Molecular Diagnostics, 2009 11(6), 662, #ST54
  11. Kelly LM, Mantha G, Durso M, Nikiforova MN. Novel Molecular Test for Detection of IDH1 Mutation in Brain Tumors, 15th Annual Meeting of Association for Molecular Pathology, Journal of Molecular Diagnostics, 2009 11(6), 662, #ST55
  12. Nikiforov AY, Kelly LM, Seethala RS, Mantha GS. MicroRNA Expression Profiling as a Tool for Diagnosis of Salivary Duct Tumors 15th Annual Meeting of Association for Molecular Pathology, Journal of Molecular Diagnostics, 2009 11(6), 662, #ST26
  13. Kelly LM; Nikiforova MN; Hodak SP; Carty SE; Luo J; Nikiforov YE. Next Generation Sequencing Analysis to Discover Novel Mutations in Thyroid Cancer. UPCI Scientific Retreat 2012.
  14. Kelly LM; Nikiforova MN; Hodak SP; Carty SE; Nikiforov YE. Prevalence and potential diagnostic use of rare mutations found by extended genotyping of 501 papillary thyroid carcinomas. 82nd Annual Meeting of the American Thyroid Association, 2012.
  15. Kelly LM; Liu P; Nikiforova MN; Hodak SP; Carty SE; Luo J; Nikiforov YE. Next Generation Sequencing Analysis to Discover Novel Mutations in the Follicular Variant of Papillary Thyroid Cancer. 82nd Annual Meeting of the American Thyroid Association, 2012, Short Call Abstract and Presentation.

Grant:

  1. ATA Fellows' Grant for the 82nd Annual Meeting of the American Thyroid Association, 2012.

Awards: