Pathology Graduate Training Program
Cellular and Molecular Pathology (CMP) -
Current Graduate Students

Name: Julie Chandler
Email: juc24@pitt.edu
Lab Phone: 412-235-5214
Mentor Name:Eric Lagasse, Ph.D

Undergraduate Education:
Undergraduate Degree: B.S. in Biology
Undergraduate Institution: Youngstown State University

Research Project Information:

Intrinsic differences between small and large intestinal stem cells may account for the increased incidence of human colon cancer.

Publications

Sun J, Sun Q, Brown MF, Dudgeon C, Chandler J, Xu X, Shu Y, Zhang L, Yu J. The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA. PLoS One. 2012. 7(8):e43158.

Chandler JM, Treece ER, Trenary HR, Brenneman JL, Flickner TJ, Frommelt JL, Oo ZM, Patterson MM, Rundle WT, Valle OV, Kim TD, Walker GR, Cooper CR. Protein profiling of the dimorphic, pathogenic fungus, Penicillium marneffei. Proteome Science. 2008. June 4; 6:17.

Chandler JM, Francipane MG, Lagasse E: Cancer Stem Cells: A Moving Target. Current Pathobiology Reports 2013, 1(2):111-118. MGF and JMC contributed equally to this work.

Chandler JM, Trenary, HR, Walker GR, Cooper CR: Capillary Electrophoresis for Protein Profiling of the Dimorphic, Pathogenic Fungus, Penicillium marneffei. Methods Mol Biol, 2013. 984: p. 275-84.

Chandler JM, Lagasse E: Cancerous stem cells: deviant stem cells with cancer-causingmisbehavior. Stem Cell Research & Therapy 2010, 1(2):13.

Chandler JM, Treece ER, Trenary HR, Brenneman JL, Flickner TJ, Frommelt JL, Oo ZM, Patterson MM, Rundle WT, Valle OV, Kim TD, Walker GR, Cooper CR. Protein profiling of the dimorphic, pathogenic fungus, Penicillium marneffei. Proteome Science. 6:17. 2008.

Abstracts:

Francipane, MG, Chandler J, and Lagasse E. Targeting the mTOR Pathway in Colon Cancer Stem Cells. 6th Annual Ri.Med Foundation Symposium.Palermo, Italy. October 2012.

Sun J, Sun Q, Brown M, Dudgeon, C, Chandler J, Zhang L, Yu J. The multi-targeted kinase inhibitor Sunitinib induces apoptosis in colon cancer cells via PUMA. AACR Annual Meeting. Chicago, IL, April 2012.

Chandler J, Lagasse E. From cancerous stem cells to goblet cells: A therapeutic approach for colon cancer. Colorectal Cancer: Biology to Therapy. AACR. Philadelphia, PA, October 2010.

Chandler JM, Treece ER, Kim TD, Cooper CR Jr., Coschigano PW. Proteomic Analysis of Anaerobic p-Cresol Metabolism by Thauera aromatica strain T1. Annual Meeting of the American Society for Microbiology, Toronto, Ontario, Canada. May 2007

Cooper CR Jr., Chandler JM, Treece ER, Kim TD, Walker GR. Protein Profiling of Dimorphism in the Fungal Pathogen, Penicillium marneffei. Eighth International Mycological Congress, Carins, Australia. August 22, 2006.

Chandler JM, Treece ER, Kim TD, Walker GR, Cooper CR Jr. Yeast Phase Protein Profiling of the Dimorphic Fungal Pathogen, Penicillium marneffei. ASM Conference on Dimorphic Fungal Pathogens, Denver, Colorado. March 2006.

Kim TD, Trenary H, Chandler J, Cooper CR Jr. Proteomic Profiling of Dimorphism in Penicillium marneffei. International Union of Biochemistry and Molecular Biology/American Society of Biochemistry and Molecular Biology, Boston, MA, June 2004.

Oral Presentations:

Chandler JM, Lagasse, E. Identification of distinct stem cells in the human small and large intestine: A tale of two cells. Vertex Pharmaceuticals, Inc. Boston, MA. April 2013. Invited talk.

Chandler JM, Lagasse, E. Two distinct stem cells in the human small and large intestine. Experimental Biology 2013. Boston, MA. April 2013. Concurrent Session: Stem Cell Biology and Molecular Profiling in Malignancies.

Chandler JM, Lagasse E. Colon Cancer: A Stem Cell Disease? University of Pittsburgh Cancer Institute Annual Retreat. Pittsburgh, PA, June 2012.

Chandler JM, Treece ER, Kim TD, Cooper CR Jr., Proteomic Profiling of dimorphism in Penicillium Marneffei: A pathogenic fungus. OASOBASM-Youngstown State University. April 2004.