MSCMP 2730
Molecular Mechanisms of Tissue Growth and Differentiation   (SPRING ONLY)  (03.0 Cr)
This course covers the anatomy, embryology, histology, function, and growth regulation (growth factors, receptors, and signaling pathways) of various differentiated tissues. Multidisciplinary lectures are given by faculty who have ongoing research in these areas. The course is designed to offer detailed information on specific tissues, tissue-tissue interactions, and overlapping cellular and molecular pathways that exist in multiple tissues.

MSCMP 2740
Pathobiology   (SPRING ONLY)   (03.0 Cr)
This course is organized in a modular format to examine in depth five human diseases of various tissue origin. Faculty will present the clinical presentation of patients with each disease, discuss the pathologic findings and molecular mechanisms underlying the disease, and the latest molecular techniques utilized in the diagnosis and treatment for each disease. Students will present papers relevant to the disease topics and be graded on their classroom participation and presentations. The human diseases covered in this course will change from year to year.

MSCMP 2750
Research Seminar   (SPRING AND FALL)   (01.0 Cr)
Students present their research or a recent research article from a broad range of topics selected by the student in consultation with a faculty advisor. The course meets weekly during which the student presents his/her research in progress or an article of his/her choice. Emphasis is placed on a careful analysis and critical evaluation of the manuscript as well as the development of teaching and speaking skills needed for scientific presentation. The student is expected to elucidate issues relevant to the topic and to answer questions from other graduate students and faculty.

MSCMP 2760
Intro to Tissue Engineering    (SPRING ONLY)    (03.0 Cr)
The purpose of this course is to introduce students to tissue engineering. Tissue engineering is defined as the development and manipulation of laboratory-grown molecules, cells, tissues, or organs to replace and/or support the function of injured body parts. Tissue engineering is highly interdisciplinary and therefore crosses numerous engineering and medical specialties. Upon completing this course, the graduate and undergraduate students should:

• understand the basic principles behind human cell and tissue biology and cell
• be familiar with the general types of biomaterials used in tissue engineering,
• understand techniques utilized to design, fabricate, and functionally assess tissue engineering systems
• apply the combined knowledge of tissue organization and tissue engineering strategies to design a unique, reasonable tissue engineering solution.

This five-part course covers cell and tissue biology, biomaterials, drug delivery, engineering methods and design, and clinical implementation.

MSCMP 2770
Angiogenesis: Molecular Pathways and Pathophysiological Functions    (SPRING ONLY)   (03.0 Cr)
This course will provide extend basic knowledge of developmental, cellular, molecular biology of angiogenesis and most recent advancements in its clinical applications. Topics include: 1. Angiogenesis in physiological and pathological process; 2. Molecular and cellular regulation of angiogenesis; 3. Current advance in angiogenic therapies. Recent outstanding research publications will also be discussed.

MSCMP 2780
Special Topics   (03.0 Cr)
One or more student(s) will focus on a selected topic (usually defined by the students) in Experimental Pathologyand discuss the primary literature pertaining to the topic. Students will be evaluated on their discussions and presentations, and write a paper under the direction of a faculty advisor.

MSCMP 2790
Directed Study   (01.01 to 0.90 Cr)
This course provides the student an opportunity to carry out a specific laboratory project in any area of interest in Experimental Pathology.

MSCMP 3700
PhD Dissertation Research   (01.0 to 14.0 Cr)
After advancement to candidacy for the Ph.D. degree, students enroll in this course to pursue original experimental laboratory research, the results of which will provide the substance of their doctoral dissertation. A minimum of 40 credits of this course are required for the Ph.D. degree in the School of Medicine.

MSCMP 3710
Cancer Biology and Therapeutics   (FALL ONLY)   (03.0 Cr)
This presents biochemical and clinical aspects of cancer biology and therapy and is designed for graduate students in basic sciences or medicine. The lectures will cover: Biology of Normal and Neoplastic Cells, Mechanisms of Neoplastic Transformation, Chemical and Environmental Carcinogenesis, Viral Oncogenesis, Breast and Prostate Cancer, Chemotherapy, Radiotherapy, Gene Therapy, Tumor Immunology, and Nutrition and Cancer.

MSCMP 3715
Bioinformatics in Cancer Biology and Therapeutics    (01.0 Cr)
Reading and discussion of bioinformatic resources available for enhancing research in cancer biology and therapeutics. We will discuss bioinformatics databases and other resources related to: regulatory networks and signal transduction pathways, genes associated with cancer risk and the progression of cancer; cytogenetics, sources of information on the distribution of cancer occurrence and trends in the US population, databases DNA repair genes, their structure & function, models of cancer progression & responses to therapy, biomarkers for cancer detection, treatment & prevention.

MSCMP 3730
Topics in Experimental Neuropathology   (SPRING AND FALL)   (01.0 Cr)
This course meets once every other week to critically evaluate the latest scientific literature concerning diseases of the central nervous system. Participants include the faculty, residents, and fellows within the Division of Neuropathology. Emphasis will be placed on methodologies as they are applied to the study of human neurologic diseases, with discussion of the most recent hypotheses concerning cellular and molecular mechanisms that cause human disease. Student participants will present scientific papers and lead the classroom discussion.

MSCMP 3740
Stem Cells  (FALL ONLY)   (03.0 Cr)
The goals of this course are to provide a comprehensive knowledge of stem cell biology, with emphasis on the characterization of tissue specific stem cells and their role in health and disease.

MSCMP 3760
Regenerative Medicine Research Seminar   (SPRING AND FALL)   (01.0 Cr)
The seminar in regenerative medicine is geared towards providing updated information on topics in the field of regenerative medicine, tissue engineering and stem cell applications. Through biweekly seminars, the students will be acquainted to the recent advances in the ever-growing field of regenerative medicine. Experienced faculty will deliver lectures in this seminar series.

MSCMP 3770
Cell Therapy    (SUMMER ONLY)   (03.0 Cr)
The topic of this course closely interfaces with the areas of gene therapy, stem cell biology, immunology, and tissue engineering. The focus specifically on cellular therapy, which is contrasted to tissue engineering and biohybrid organ engineering wherein a tissue construct of hybrid organ is created ex vivo. At the conclusion of this course students are expected to know the mechanics of rejection of cellular transplants from both allotypic and xenotypic sources; be familiar with strategies to avoid transplant rejection, know the technologies and strategies applied to the isolation, expansion, and preservation of cells for transplantation; and be familiar with the application of cellular therapy techniques to a variety of disease states.

MSCMP 3780
Systems Approach to Inflammation    (FALL ONLY)  (02.0 Cr)
This course is focused on particular topics of great biologic complexity in critical illness, where modeling has the potential to translate in improved patient care. Lectures are provided by basic (biological and mathematical sciences) and clinical faculty, in conjunction with members of industry and speakers from outside institutions. This information will be communicated within the framework of defined themes that describe the complexity of inflammation in acute and chronic illnesses.